Time-restricted feeding alters isoflurane-induced memory deficits.
Time-restricted feeding alters isoflurane-induced memory deficits.
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限时喂养可改变异氟烷引起的记忆缺陷
DOI：
10.1515/tnsci-2020-0130
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发表时间：
2020
影响因子：
2.1
通讯作者：
Gu X
中科院分区：
文献类型：
--
作者：
Song J;Chu S;Fang X;Xu F;Zhang P;Zhao X;Ma Z;Xia T;Gu X
在休息阶段的食物消耗促进昼夜节律，这是纠正有害的生理和精神障碍。以前，我们发现昼夜节律紊乱与异氟醚引起的认知障碍有关。在这里，我们安排食物获取来调节每日节律，以检查其对异氟烷诱导的认知障碍的影响。将小鼠随机转移到限制喂养（RF）时间组：对照组（Zeitgeber时间（ZT）0-ZT 24，自由喂养）、日间喂养组（ZT 0-ZT 12，不对齐喂养）和夜间喂养组（ZT 12-ZT 24，对齐喂养）。从ZT 14 ~ ZT 19开始，部分动物接受1.3%异氟醚麻醉5 h，并分为对照+ Anes组、日喂+ Anes组和夜喂+ Anes组。使用Mini-Mitter监测每日节律。采用恐惧条件反射系统评价小鼠的认知能力。我们观察到，夜间喂养组逐渐适应RF，而白天喂养组表现出紊乱的每日节律。夜间喂食+ Anes组表现出部分增强的日节律，而日间喂食+ Anes组在异氟烷麻醉后7天表现出持续的相位提前和日节律评分增加。值得注意的是，在视神经依赖性背景记忆测试中，夜间喂食+ Anes组表现出减少的缺陷;日间喂食+ Anes组在异氟烷麻醉后14天表现出延长的麻醉后缺陷。然而，杏仁核依赖性线索恐惧条件反射麻醉后没有改变RF时间表。总之，我们证明，错位喂养扰乱了日常节奏，并导致持续的麻醉后认知功能障碍。同步喂养部分提高了患者的日常生活节奏，改善了麻醉后认知功能障碍。
Food consumption during the rest phase promotes circadian desynchrony, which is corrected with harmful physiological and mental disorders. Previously, we found that circadian desynchrony was involved in isoflurane-induced cognitive impairment. Here, we scheduled food access to modulate daily rhythm to examine its impact on isoflurane-induced cognitive impairments. Mice were randomly transferred to restricted feeding (RF) time groups: Control group (Zeitgeber time (ZT) 0–ZT24, ad libitum feeding), Day-Feeding group (ZT0–ZT12, misaligned feeding), and Night-Feeding group (ZT12–ZT24, aligned feeding). Then, some of them were subjected to 5 h of 1.3% isoflurane anaesthesia from ZT14 to ZT19 and were divided into the Control + Anes group, the Day-Feeding + Anes group, and the Night-Feeding + Anes group. Mini-Mitter was used to monitor the daily rhythm. Fear conditioning system was conducted to assess cognition of mice. We observed that the Night-Feeding group adapted to RF gradually, whereas the Day-Feeding group exhibited a disturbed daily rhythm. The Night-Feeding + Anes group exhibited a partially enhanced daily rhythm, whereas the Day-Feeding + Anes group exhibited sustained phase advances and diurnality score increase 7 days after isoflurane anaesthesia. Notably, in tests of hippocampus-dependent contextual memory, the Night-Feeding + Anes group demonstrated decreased deficits; the Day-Feeding + Anes group showed prolonged post-anaesthetic deficits 14 days after isoflurane anaesthesia. However, amygdala-dependent cued-fear conditioning post-anaesthesia was not altered by the RF schedule. In conclusion, we demonstrated that misaligned feeding disturbed the daily rhythm and led to persistent post-anaesthetic cognitive dysfunction. Aligned feeding enhanced the daily rhythm partially and improved post-anaesthetic cognitive dysfunction.
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DOI：
10.1038/nrn2881
发表时间：
2010-08
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Gerstner JR;Yin JC
通讯作者：
Yin JC
影响因子：
2.7
作者：
Foster, Russell G.;Kreitzman, Leon
通讯作者：
Kreitzman, Leon
影响因子：
7.7
作者：
Loh, Dawn H.;Jami, Shekib A.;Colwell, Christopher S.
通讯作者：
Colwell, Christopher S.
DOI：
10.1073/pnas.0707171104
发表时间：
2007-09-18
影响因子：
11.1
作者：
Huitron-Resendiz, Salvador;Marcondes, Maria Cecilia G.;Fox, Howard S.
通讯作者：
Fox, Howard S.
影响因子：
3.7
作者：
Gibson EM;Wang C;Tjho S;Khattar N;Kriegsfeld LJ
通讯作者：
Kriegsfeld LJ