EEG event related potentials in sustained, focused and divided attention tasks: Potential biomarkers for cognitive impairment in HIV patients.
EEG event related potentials in sustained, focused and divided attention tasks: Potential biomarkers for cognitive impairment in HIV patients.
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持续、集中和分散注意任务中的脑电事件相关电位：HIV患者认知障碍的潜在生物标志物。
DOI：
10.1016/j.clinph.2020.11.026
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
本研究的目的是评估事件相关电位（ERPs）在持续、集中和分散注意力任务中的可用性，作为HIV患者认知能力下降的生物标志物。采用移动/无线9通道系统采集39例免疫功能控制良好的HIV感染者和63例健康对照者（hc）在持续注意、集中注意和分散注意三个ERP任务中的脑电图。与HC组相比，hiv组在所有任务中表现出较小的晚期阳性电位（LPP）和较大的P200振幅。P200振幅与估计感染时间相关（r = 0.56）。两组在低频率刺激下均表现出较高的P200和LPP振幅；这一效应在两组间无显著差异。在持续注意力任务中，hiv组的反应时间明显比对照组慢，但保持了相同的准确性。在分散注意力任务中，hiv组表现出更快/更不准确的反应趋势。接受抗逆转录病毒治疗（ART）的HIV血清阳性参与者在三种不同的注意力任务中表现出显著较大的P200振幅。这可能反映了以过度关注非目标/分散注意力刺激为特征的注意力缺陷。这些发现证明了来自注意力任务的EEG-ERP指标作为HIV的神经认知生物标志物的潜在益处。这种方法可能揭示HIV患者注意力缺陷的潜在原因。
The objective of this study was to assess the usability of event-related-potentials (ERPs) during sustained, focused, and divided attention tasks as biomarkers for cognitive decline in HIV patients. EEG was acquired using a mobile/wireless 9-channel system in 39 persons with HIV, with well-controlled immune function and 63 healthy control participants (HCs) during three ERP tasks: sustained attention, focused attention, and divided attention. The HIV-group evidenced smaller late positive potential (LPP) and larger P200 amplitudes across the tasks compared to the HC group. P200 amplitude was correlated (r = 0.56) with the estimated duration of infection. Both groups showed higher P200 and LPP amplitudes in response to infrequent stimuli; this effect was not significantly different between groups. In the sustained attention task, the HIV-group showed significantly slower reaction time than controls while maintaining the same level of accuracy. In the divided attention task, the HIV-group showed a trend towards faster/less accurate responses. HIV seropositive participants receiving anti-retroviral treatment (ART) demonstrated significantly larger P200 amplitude during three different attention tasks. This may reflect attentional deficits characterized by over-attending to non-target/distracting stimuli. These findings demonstrate the potential benefits of EEG-ERP metrics derived from attention tasks as neurocognitive biomarkers for HIV. This approach may reveal underlying causes of attentional deficits in HIV patients.
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影响因子：
3
作者：
Barry, Robert J.;Clarke, Adam R.;Heaven, Patrick C. L.
通讯作者：
Heaven, Patrick C. L.
影响因子：
4.7
作者：
Babiloni, Claudio;Pennica, Alfredo;Andreoni, Massimo
通讯作者：
Andreoni, Massimo
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
11.3
作者：
Bauer, Lance O.
通讯作者：
Bauer, Lance O.
影响因子：
1.8
作者：
COLES, MGH;SCHEFFERS, MK;FOURNIER, L
通讯作者：
FOURNIER, L