Insertional inactivation of virR in Streptococcus pyogenes M49 demonstrates that VirR functions as a positive regulator of ScpA, FcRA, OF, and M protein.
Insertional inactivation of virR in Streptococcus pyogenes M49 demonstrates that VirR functions as a positive regulator of ScpA, FcRA, OF, and M protein.
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virR 在化脓性链球菌 M49 中的插入失活表明 VirR 作为 ScpA、FcRA、OF 和 M 蛋白的正调节因子发挥作用。
DOI:
10.1111/j.1574-6968.1995.tb07498.x
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发表时间:
1995
影响因子:
2.1
通讯作者:
Cleary,PP
中科院分区:
文献类型:
--
作者:
McLandsborough,LA;Cleary,PP
Several reports have shown thatStreptococcus pyogenesstrains which produce opacity factor (OF+) have diverged significantly from OF−serotypes. This study questions whether several surface proteins of an OF+ culture are regulated by the positive regulatory protein VirR, in a manner similar to OF~ strains. Interruption of the virR region of an OF+S. pyogenes(strain CS101, M type 49) was performed using a temperature-sensitive plasmid containing a fragment ofvirR. Interruption of thevirRregion produced cultures with (indétectable amounts of M49 and ScpA proteins, and reduced the yield of FcRA protein. In addition, mutants had a significant reduction in detectable opacity factor. These results suggest thatvirRfunctions as a positive regulator of a variety of surface proteins in OF+strains.
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影响因子:
2.1
作者:
G. Saravani;D. Martin
通讯作者:
D. Martin
影响因子:
3.1
作者:
J. Perez;H. F. Dillon;L. Husmann;B. Graham;J. R. Scott
通讯作者:
J. R. Scott
影响因子:
3.2
作者:
PEREZCASAL, J;CAPARON, MG;SCOTT, JR
通讯作者:
SCOTT, JR
影响因子:
3.1
作者:
P. Cleary;Z. Johnson;L. Wannamaker
通讯作者:
L. Wannamaker
影响因子:
15.9
作者:
Cleary,P;Retnoningrum,D
通讯作者:
Retnoningrum,D