Reliable quantification of marrow fat content and unsaturation level using in vivo MR spectroscopy.
Reliable quantification of marrow fat content and unsaturation level using in vivo MR spectroscopy.
复制标题
DOI：
10.1002/mrm.26828
复制
发表时间：
2018-03
影响因子：
3.3
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Xu K;Sigurdsson S;Gudnason V;Hue T;Schwartz A;Li X
目的：建立一种新的在体磁共振波谱（MRS）定量骨髓脂肪含量和组成的方法。提出了一种结合Voigt线形模型和时域分析优点的MRS量化方法。使用计算机模拟数据和23名受试者（83.8 ± 3.7岁，10名女性）L1至L4腰椎椎体的体内数据对所提出的方法进行了测试。计算定量结果的可靠性和重现性。并与传统方法进行了比较。计算机模拟的低平均绝对百分比误差（MAPE）和低平均变异系数（MCV）表明所提出的方法是准确和精确的。通过使用该方法，即使对于具有低光谱分辨率和低信噪比（SNR）的数据，也可以可靠地定量骨髓脂肪含量。对于具有中等光谱分辨率和中等SNR的数据，可以可靠地量化不饱和度水平。使用所提出的方法从体内数据中获得的结果表明比传统方法更好的模型拟合。本研究提出的方法在骨髓MRS数据的定量方面比传统方法有更好的性能，并且在研究骨髓脂肪含量和组成方面具有广泛的应用潜力。
To develop a novel technique for reliable quantification of bone marrow fat content and composition using in vivo magnetic resonance spectroscopy (MRS). A MRS quantification method combining both advantages of Voigt line-shape model and time-domain analysis is developed. The proposed method was tested using computer simulated data and in vivo data acquired at lumbar vertebral bodies of 23 subjects (83.8 ± 3.7 years, 10 females) from L1 to L4. Reliability and reproducibility were calculated for the quantification results. Comparisons between the proposed method and some conventional methods were conducted. Low mean absolute percentage errors (MAPE) and low mean coefficients of variation (MCV) for computer simulations suggest that the proposed method is accurate and precise. By using this method, marrow fat content can be reliably quantified even for data with low spectral resolution and low signal-to-noise ratio (SNR). Unsaturation level can be reliably quantified for data with moderate spectral resolution and moderate SNR. Results obtained from in vivo data using the proposed method demonstrated better model fit than conventional methods. The method proposed in this study has better performance than conventional methods in the quantification of bone marrow MRS data, and has great potential for wide applications of studying marrow fat contents and composition.
登录
查看更多内容
DOI：
10.1038/oby.2010.106
发表时间：
2011-01
期刊：
Obesity (Silver Spring, Md.)
影响因子：
--
作者：
Bredella MA;Torriani M;Ghomi RH;Thomas BJ;Brick DJ;Gerweck AV;Rosen CJ;Klibanski A;Miller KK
通讯作者：
Miller KK
影响因子：
2.5
作者：
JENSEN, KE;JENSEN, M;HENRIKSEN, O
通讯作者：
HENRIKSEN, O
影响因子：
3.3
作者：
Marshall, I;Higinbotham, J;Freise, A
通讯作者：
Freise, A
影响因子：
4.4
作者：
Bernard, Clare P.;Liney, Gary P.;Langton, Christian M.
通讯作者：
Langton, Christian M.
影响因子：
3.3
作者：
Karampinos, Dimitrios C.;Melkus, Gerd;Baum, Thomas;Bauer, Jan S.;Rummeny, Ernst J.;Krug, Roland
通讯作者：
Krug, Roland