Substrains of inbred mice differ in their physical activity as a behavior.
Substrains of inbred mice differ in their physical activity as a behavior.
复制标题
DOI：
10.1155/2013/237260
复制
发表时间：
2013
影响因子：
--
通讯作者：
Adamo S
中科院分区：
文献类型：
--
作者：
Coletti D;Berardi E;Aulino P;Rossi E;Moresi V;Li Z;Adamo S
最近的研究加强了这样一种信念，即身体活动作为一种行为具有遗传基础。在近交系小鼠品系中筛选车轮运行行为突出了品系之间的差异，表明即使是非常有限的遗传差异也会深刻影响小鼠的行为。我们将这一观察结果扩展到同一近交系小鼠品系的亚系，即BALB/c小鼠。我们发现，只有少数的人口的这些substrains之一，BALB/c J，进行自发的体力活动。此外，该亚系的跑步者比另外两个亚系，即BALB/c ByJ和BALB/c AnNCrl的平均跑步者覆盖的距离显著更小。后者表现出惊人的自愿活动水平，平均每天跑步距离达到约12公里。这些跑步者并不是出类拔萃的，但他们代表了大多数人口，在实验计划中要考虑到重要的科学和经济后果。自发活动在病理条件下持续存在，例如癌症相关的恶病质。这一重要的体力活动量会导致肌肉在三周内对耐力运动产生轻微的适应;事实上，在这段时间内，NADH转移酶+纤维的增加并不显著。
Recent studies strengthen the belief that physical activity as a behavior has a genetic basis. Screening wheel-running behavior in inbred mouse strains highlighted differences among strains, showing that even very limited genetic differences deeply affect mouse behavior. We extended this observation to substrains of the same inbred mouse strain, that is, BALB/c mice. We found that only a minority of the population of one of these substrains, the BALB/c J, performs spontaneous physical activity. In addition, the runners of this substrain cover a significantly smaller distance than the average runners of two other substrains, namely, the BALB/c ByJ and the BALB/c AnNCrl. The latter shows a striking level of voluntary activity, with the average distance run/day reaching up to about 12 kilometers. These runners are not outstanders, but they represent the majority of the population, with important scientific and economic fallouts to be taken into account during experimental planning. Spontaneous activity persists in pathological conditions, such as cancer-associated cachexia. This important amount of physical activity results in a minor muscle adaptation to endurance exercise over a three-week period; indeed, only a nonsignificant increase in NADH transferase+ fibers occurs in this time frame.
登录
查看更多内容
影响因子：
2.9
作者：
Knab, Amy M.;Bowen, Robert S.;Moore-Harrison, Trudy;Hamilton, Alicia Trynor;Turner, Michael J.;Lightfoot, J. Timothy
通讯作者：
Lightfoot, J. Timothy
影响因子：
8.9
作者：
Penna, Fabio;Busquets, Silvia;Argiles, Josep M.
通讯作者：
Argiles, Josep M.
影响因子：
2.5
作者：
Arida, RM;Scorza, CA;Cavalheiro, EA
通讯作者：
Cavalheiro, EA
影响因子：
3.2
作者：
Hellyer NJ;Nokleby JJ;Thicke BM;Zhan WZ;Sieck GC;Mantilla CB
通讯作者：
Mantilla CB
影响因子：
7.4
作者：
Boveris, Alberto;Navarro, Ana
通讯作者：
Navarro, Ana