The epidemiology of primary headaches in patients with multiple sclerosis.
The epidemiology of primary headaches in patients with multiple sclerosis.
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多发性硬化症患者原发性头痛的流行病学
DOI：
10.1002/brb3.1830
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发表时间：
2021-01
影响因子：
3.1
通讯作者：
Wang Y
中科院分区：
文献类型：
--
作者：
Wang L;Zhang J;Deng ZR;Zu MD;Wang Y
最近的研究表明头痛和多发性硬化症（MS）之间存在病理生理学联系，但MS患者原发性头痛的患病率在不同研究中差异很大。这项Meta分析旨在全面收集现有证据，以估计MS患者原发性头痛的患病率。我们系统地检索了包括PubMed、Embase和Scopus在内的电子数据库，以进行队列、病例对照、测量MS患者头痛患病率的横断面研究。两名评审员独立筛选标题和摘要，以确定合格的研究和纳入的全文。研究进行了审查。采用纽卡斯尔渥太华量表（NOS）评估纳入文献的偏倚风险。然后，我们使用Stata Software 15.0进行了Meta分析，以计算MS患者中头痛的合并患病率，并评估异质性的来源。我们确定了16项合格的研究，共涵盖3,560例MS患者。MS患者原发性头痛的合并估计患病率为56%。统计学异质性为中度，I2为82.1%（p < .001）。漏斗图的目视检查和Egger回归检验均未发现显著的发表偏倚（p = 0.44）。偏头痛的合并估计患病率（55%）高于紧张型头痛（20%）。无先兆偏头痛和有先兆偏头痛亚型的患病率分别为16%和10%。病例对照组中原发性头痛的合并患病率（57%）与横断面组（56%）大致一致。MS患者原发性头痛的总体患病率相当高。对MS患者进行头痛的临床筛查，将有助于制定个体化治疗方案，减轻疾病对身心的影响。这项Meta分析旨在全面收集现有证据，以估计MS患者中原发性头痛的患病率。MS患者中原发性头痛的总体患病率相当高。对MS患者进行头痛的临床筛查，将有助于制定个体化的治疗方案，减轻疾病对身体和精神的影响。
Recent studies have shown a pathophysiologic link between headache and multiple sclerosis (MS), but the prevalence of primary headaches among patients with MS differs substantially across studies. This meta‐analysis aimed to comprehensively gather available evidence to estimate the prevalence of primary headaches among patients with MS. We systematically searched the electronic databases including PubMed, Embase, and Scopus for cohort, case–control, cross‐sectional studies that measured the prevalence of headache among patients with MS. Two reviewers independently screened titles and abstracts to identify the eligible studies and the full texts of the included studies were reviewed. Newcastle‐Ottawa Scale (NOS) was used to assess the risk of bias of the included literatures. We then conducted a meta‐analysis using Stata Software 15.0 to calculate the pooled prevalence of headaches among patients with MS and assess the source of heterogeneity. We identified 16 eligible studies covering a total of 3,560 patients with MS. The pooled estimated prevalence of primary headaches among patients with MS was 56%. The statistical heterogeneity was moderate with I 2 of 82.1% (p < .001). Both a visual inspection of the funnel plot and Egger’ regression tests revealed no significant publication bias (p = .44). The pooled estimated prevalence of migraine (55%) was higher in comparison with that of tension‐type headache (20%). The prevalence of migraine subtype was 16% and 10% for migraine without aura and migraine with aura, respectively. The pooled prevalence of primary headache in case–control group (57%) was approximately in line with the cross‐sectional group (56%). The overall prevalence of primary headaches among patients with MS was considerably high. Clinical screening of headache among patients with MS will be helpful to formulate an individualized treatment plans and alleviate the physical and mental impact of the disease. This meta‐analysis aimed to comprehensively gather available evidence to estimate the prevalence of primary headaches among patients with MS. The overall prevalence of primary headaches among patients with MS was considerably high. Clinical screening of headache among patients with MS will be helpful to formulate a individualized treatment plans and alleviate the physical and metal impact of the disease.
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影响因子：
7.4
作者：
Kister, Ilya;Caminero, A. B.;Monteith, T. S.;Soliman, A.;Bacon, T. E.;Bacon, J. H.;Kalina, J. T.;Inglese, M.;Herbert, J.;Lipton, R. B.
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通讯作者：
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影响因子：
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通讯作者：
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影响因子：
3.3
作者：
Cristiano, E.;Patrucco, L.;Rojas, J. I.
通讯作者：
Rojas, J. I.