An initial investigation of the orbitofrontal cortex hyperactivity in obsessive-compulsive disorder: exaggerated representations of anticipated aversive events?
An initial investigation of the orbitofrontal cortex hyperactivity in obsessive-compulsive disorder: exaggerated representations of anticipated aversive events?
复制标题
DOI：
10.1016/j.neuropsychologia.2009.03.018
复制
发表时间：
2009-08
期刊：
影响因子：
2.6
通讯作者：
Carter CS
中科院分区：
文献类型：
--
作者：
Ursu S;Carter CS
眶额皮质（OFC）功能障碍已多次参与强迫症，但这种异常的确切意义仍不清楚。目前的神经认知模型认为，眶额皮层的特定区域通过代表未来事件的预期情感价值而有助于行为调节。这导致了一个假设，即这些OFC区域在患者中过度活跃，反映了对未来厌恶事件的沉思性关注。在实验情况下，这种多动症应该是由负面影响触发的，以应对高可能性的事件，如同时活跃的不相容反应之间的冲突，这可能会导致不良的任务表现。我们通过检查15名强迫症患者和15名对照组的脑活动fMRI指数来验证这一假设。受试者在执行认知任务时被扫描，该任务涉及对线索和随后的探测做出反应，并且一些探测引起反应冲突。相对于对照组，患者的外侧眶额皮层对与高比例的后续高冲突探测相关的线索特别活跃。眶额肌功能亢进的程度与焦虑症状的严重程度直接相关。这些结果支持这一假设，即强迫症的特点是夸大OFC表示预期的厌恶事件。
Orbitofrontal cortical (OFC) dysfunction has been repeatedly involved in obsessive-compulsive disorder, but the precise significance of this abnormality is still unclear. Current neurocognitive models propose that specific areas of the OFC contribute to behavioral regulation by representing the anticipated affective value of future events. This leads to the hypothesis that these OFC areas are hyperactive in patients, reflecting ruminative preoccupation with future aversive events. In experimental situations, such hyperactivity should be triggered by negative affect in response to high likelihood of events such as the conflict between simultaneously active incompatible responses, which can potentially lead to poor task performance. We tested this hypothesis by examining fMRI indices of brain activity of fifteen OCD patients and fifteen matched controls. Subjects were scanned while performing a cognitive task which involved responding to cues and subsequent probes, and some of the probes elicited response conflict. Relative to controls, the lateral OFC of patients was specifically hyperactive to cues associated with high proportion of subsequent high-conflict probes. The level of OFC hyperactivity correlated directly with the severity of anxiety symptoms. These results support the hypothesis that OCD is characterized by exaggerated OFC representations of anticipated aversive events.
登录
查看更多内容
影响因子：
--
作者：
Remijnse, Peter L.;Nielen, Marjan M. A.;Veltman, Dick J.
通讯作者：
Veltman, Dick J.
影响因子：
2.3
作者：
Alptekin, K;Degirmenci, B;Tunca, Z
通讯作者：
Tunca, Z
影响因子：
25
作者：
O'Doherty, J;Kringelbach, ML;Andrews, C
通讯作者：
Andrews, C
影响因子：
10.6
作者：
Rauch, Scott L.;Wedig, Michelle M.;Wilhelm, Sabine
通讯作者：
Wilhelm, Sabine
影响因子：
5.7
作者：
Remijnse, PL;Nielen, MMA;Veltman, DJ
通讯作者：
Veltman, DJ