Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome.
Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome.
复制标题
鼻内催产素对易碎X综合征男性社交焦虑的影响。
DOI：
10.1016/j.psyneuen.2011.07.020
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发表时间：
2012-04
影响因子：
3.7
通讯作者：
Reiss, Allan L.
中科院分区：
文献类型：
--
作者：
Hall, Scott S.;Lightbody, Amy A.;McCarthy, Brigid E.;Parker, Karen J.;Reiss, Allan L.
脆性X综合征（FXS）是一种罕见的遗传性遗传疾病，可导致严重的智力残疾和自闭症样症状。患有FXS的个体，尤其是男性，在遇到有压力的社交场合时，往往会表现出极端的目光回避和过度觉醒。我们调查了催产素（OT），一种具有亲社会和抗焦虑作用的激素，是否可以减轻这一人群的社交焦虑症状。进行了一项随机、双盲、安慰剂对照、单次给药试验，鼻内给予安慰剂、24 IU OT和48 IU OT。眼凝视频率，心率，呼吸性窦性心律不齐（RSA），心率变异性（HRV）和唾液皮质醇的措施，获得在一个结构化的社会挑战进行OT管理后50分钟。10名患有FXS的低功能男性（年龄13-28岁）前往斯坦福大学进行首次访视：8名完成了研究。眼凝视频率响应于24 IU OT剂量显著改善，唾液皮质醇水平响应于48 IU OT剂量显著降低。OT对心率、RSA或HRV没有影响，尽管心率数据的个体图表明OT增加了一些参与者的心率，降低了其他参与者的心率。这些研究结果表明，鼻内给药OT可以改善FXS患者的社交焦虑症状。进一步的双盲安慰剂对照研究，结合行为治疗计划进行，可能是必要的。
Fragile X syndrome (FXS) is a rare inherited genetic disorder causing severe intellectual disability and autistic-like symptoms. Individuals with FXS, males in particular, often exhibit extreme eye gaze avoidance and hyperarousal when they encounter stressful social situations. We investigated whether oxytocin (OT), a hormone with prosocial and anxiolytic effects, could alleviate symptoms of social anxiety in this population. A randomized double-blind placebo-controlled single-dose trial was performed with intranasal administration of placebo, 24 IU OT and 48 IU OT. Measures of eye gaze frequency, heart rate, respiratory sinus arrhythmia (RSA), heart rate variability (HRV) and salivary cortisol were obtained during a structured social challenge conducted 50 min following OT administration. Ten low-functioning males with FXS (aged 13–28 years) traveled to Stanford for the initial visit: 8 completed the study. Eye gaze frequency improved significantly in response to the 24 IU OT dose and salivary cortisol levels decreased significantly in response to the 48 IU OT dose. There was no effect of OTon heart rate, RSA or HRV although individual plots of the heart rate data suggested that OT increased heart rate in some participants and decreased heart rate in others. These findings suggest that intranasal administration of OT may ameliorate some symptoms of social anxiety in patients with FXS. Further double-blind placebo-controlled studies of OT, conducted in combination with behavioral treatment programs, may be warranted.
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影响因子：
2.9
作者：
Hall, Scott S.;Maynes, Natalee P.;Reiss, Allan L.
通讯作者：
Reiss, Allan L.
影响因子：
10.6
作者：
Epperson, CN;McDougle, CJ;Price, LH
通讯作者：
Price, LH
影响因子：
10.6
作者：
Guastella, Adam J.;Einfeld, Stewart L.;Hickie, Ian B.
通讯作者：
Hickie, Ian B.
影响因子：
3.7
作者：
Hessl, D;Glaser, B;Reiss, AL
通讯作者：
Reiss, AL
影响因子：
10.6
作者：
Guastella, Adam J.;Mitchell, Philip B.;Dadds, Mark R.
通讯作者：
Dadds, Mark R.