Proinflammatory cytokines correlate with early exercise attenuating anxiety-like behavior after cerebral ischemia.
Proinflammatory cytokines correlate with early exercise attenuating anxiety-like behavior after cerebral ischemia.
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促炎细胞因子与早期运动减轻脑缺血后焦虑样行为相关
DOI：
10.1002/brb3.854
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发表时间：
2017-11
影响因子：
3.1
通讯作者：
Xia R
中科院分区：
文献类型：
--
作者：
Zhang Q;Zhang J;Yan Y;Zhang P;Zhang W;Xia R
中风可能会导致神经精神问题，对认知功能和行为产生负面影响。运动对减少脑卒中的发生和发展起着重要作用，具体机制尚不完全清楚。在这项研究中，我们试图确定早期跑步机运动是否通过调节脑缺血后的炎症来减轻焦虑样行为。成年雄性大鼠大脑中动脉闭塞（MCAO）90分钟，训练大鼠从术后第1天到第14天开始在跑步机上跑步。采用Morris水迷宫试验、旷场试验、高架十字迷宫试验和酶联免疫吸附试验分析跑步机对认知功能、焦虑样行为和免疫激活的影响。早期跑台运动可显著改善缺血大鼠模型的认知功能，减轻焦虑样行为;这种改善与星形胶质细胞和小胶质细胞活化和促炎标志物（血小板活化因子[PAF]、白细胞介素-6 [IL-6]、肿瘤坏死因子-α [TNF-α]、细胞间粘附分子-1 [ICAM-1]和血管细胞粘附分子-1 [VCAM-1]）显著降低相关。我们的研究结果表明，早期跑步机运动通过减少炎症反应来减轻焦虑样行为，运动通过抗炎治疗减轻焦虑样行为的巨大益处可能被证明是中风的一种新的神经保护策略。
Stroke may cause neuropsychiatric problems, which have negative effects on cognitive functions and behavior. Exercise plays an important role in reducing the occurrence and development of stroke, the concrete mechanism is not fully clarified. In this study, we attempted to determine whether early treadmill exercise attenuates anxiety‐like behavior by regulation of inflammation after brain ischemia. We subjected adult male rats to middle cerebral artery occlusion (MCAO) for 90 min and trained rats started to run on a treadmill from postoperative day 1 to day 14. The effects of treadmill on cognitive functions, anxiety‐like behavior, and immune activation were analyzed by Morris water maze test, open field test, elevated plus maze test, and enzyme‐linked immunosorbent assay. Early treadmill exercise significantly improved cognitive function, alleviated anxiety‐like behavior in ischemic rats model; this improvement was associated with significantly decreased activation of astrocytes and microglia cells and proinflammatory markers (platelet‐activating factor [PAF], interleukin‐6 [IL‐6], tumor necrosis factor‐alpha [TNF‐α], intercellular adhesion molecule‐1 [ICAM‐1], and vascular cell adhesion molecule‐1 [VCAM‐1]). Our results indicated that early treadmill exercise attenuated anxiety‐like behavior by decreasing inflammation response, exercise conferred a great benefit of attenuating anxiety‐like behavior via anti‐inflammatory treatment may prove to be a novel neuroprotective strategy for stroke.
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影响因子：
--
作者：
Cheng Y;Su Q;Shao B;Cheng J;Wang H;Wang L;Lin Z;Ruan L;ZhuGe Q;Jin K
通讯作者：
Jin K
影响因子：
3.8
作者：
de Brito Toscano, Eliana Cristina;Silva, Bruno Costa;Rachid, Milene Alvarenga
通讯作者：
Rachid, Milene Alvarenga
DOI：
10.1016/j.bbi.2015.08.009
发表时间：
2016-01
期刊：
Brain, behavior, and immunity
影响因子：
--
作者：
Maldonado-Bouchard S;Peters K;Woller SA;Madahian B;Faghihi U;Patel S;Bake S;Hook MA
通讯作者：
Hook MA
早期运动通过增加实验性中风大鼠模型的血管生成来改善脑血流量
影响因子：
5.1
作者：
Zhang P;Yu H;Zhou N;Zhang J;Wu Y;Zhang Y;Bai Y;Jia J;Zhang Q;Tian S;Wu J;Hu Y
通讯作者：
Hu Y
影响因子：
--
作者：
Yan H;Fang M;Liu XY
通讯作者：
Liu XY