Cannabis use and memory brain function in adolescent boys: a cross-sectional multicenter functional magnetic resonance imaging study.
Cannabis use and memory brain function in adolescent boys: a cross-sectional multicenter functional magnetic resonance imaging study.
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DOI：
10.1016/j.jaac.2010.02.001
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发表时间：
2010-06
影响因子：
13.3
通讯作者：
Ramsey NF
中科院分区：
文献类型：
--
作者：
Jager G;Block RI;Luijten M;Ramsey NF
早发性大麻的使用与较晚的吸食(Ab)、精神健康问题(精神病、抑郁)以及认知和大脑功能的异常发展有关。在青春期，正在进行的神经发育成熟和经验塑造了记忆和执行控制等复杂认知功能背后的神经回路。前额叶和颞区在这些功能中起着至关重要的作用。成熟的过程使这些大脑区域容易受到大麻使用的潜在有害影响。我们进行了一项横断面设计的两点(美国和NL；汇集数据)功能磁共振研究，调查了21名戒毒但频繁使用大麻的男孩(13-19岁)青少年使用大麻对工作记忆(WM)和联想记忆(AM)脑功能的影响，并将他们与24名不使用大麻的同龄人进行了比较。在基于规则的学习(自动化)之前和之后，评估WM期间的大脑活动。使用图画依赖的海马区记忆任务来评估AM。吸食大麻的人在这两项记忆任务中表现正常。在工作记忆评估中，当一项任务是新的时，大麻使用者在前额叶区域表现出过度的活动，而任务的自动化将使用者和对照组的活动减少到相同的水平。未发现大麻使用对AM相关脑功能的影响。在青少年吸食大麻的人中，工作记忆系统在一项新的任务中过度活跃，这表明功能补偿。低效的WM招聘与自动化失败无关，但在处理不断变化的信息时变得明显。这些结果似乎证实了仍在发育中的额叶功能对于早发性大麻使用的脆弱性。
Early-onset cannabis use has been associated with later (ab)use, mental health problems (psychosis, depression) and abnormal development of cognition and brain function. During adolescence ongoing neurodevelopmental maturation and experience shape the neural circuitry underlying complex cognitive functions such as memory and executive control. Prefrontal and temporal regions are critically involved in these functions. Maturational processes leave these brain areas prone to the potentially harmful effects of cannabis use. We performed a two-site (US and NL; pooled data) functional MRI study with a cross-sectional design, investigating the effects of adolescent cannabis use on working memory (WM) and associative memory (AM) brain function in twenty-one abstinent but frequent cannabis using boys (age 13 – 19) and compared them with twenty-four non-using peers. Brain activity during WM was assessed before and following rule-based learning (automatization). AM was assessed using a pictorial hippocampal-dependent memory task. Cannabis users performed normally on both memory tasks. During WM assessment cannabis users showed excessive activity in prefrontal regions when a task was novel, whereas automatization of the task reduced activity to the same level in users and controls. No effect of cannabis use on AM-related brain function was found. In adolescent cannabis users the WM system was overactive during a novel task, suggesting functional compensation. Inefficient WM recruitment was not related to a failure in automatization, but became evident when processing continuously changing information. The results seem to confirm the vulnerability of still developing frontal lobe functioning for early-onset cannabis use.
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