Orbitofrontal control of conduct problems? Evidence from healthy adolescents processing negative facial affect.
Orbitofrontal control of conduct problems? Evidence from healthy adolescents processing negative facial affect.
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DOI：
10.1007/s00787-021-01770-1
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发表时间：
2022-08
影响因子：
6.4
通讯作者：
Nees, Frauke
中科院分区：
文献类型：
--
作者：
Boettinger, Boris William;Baumeister, Sarah;Millenet, Sabina;Barker, Gareth J.;Bokde, Arun L. W.;Buechel, Christian;Quinlan, Erin Burke;Desrivieres, Sylvane;Flor, Herta;Grigis, Antoine;Garavan, Hugh;Gowland, Penny;Heinz, Andreas;Ittermann, Bernd;Martinot, Jean-Luc;Martinot, Marie-Laure Paillere;Artiges, Eric;Orfanos, Dimitri Papadopoulos;Paus, Tomas;Poustka, Luise;Froehner, Juliane H.;Smolka, Michael N.;Walter, Henrik;Whelan, Robert;Schumann, Gunter;Banaschewski, Tobias;Brandeis, Daniel;Nees, Frauke
与对照组相比，破坏性行为障碍患者的行为问题(CP)与负面面部情感的前额叶加工受损有关。然而，尚不清楚在健康人群样本中，情感面孔加工过程中与前额叶活动的关联是否沿着CP维度成立，以及皮质下加工是如何受到影响的。我们测量了来自欧洲IMAGEN多中心研究的1444名健康青少年[M = 14.39岁(SD = 0.40)，51.5%女性]在负面情感面孔加工过程中的脑功能反应。为了确定CP的效果，我们采用了两步法：(A)使用方差分析测试低CP和高CP的配对亚组，扩展到临床范围[每组N = 182a，M = 14.44年，(SD = 0.41)，47.3%女性]，以及(B)在全样本和高CP组中使用多元回归考虑沿着CP维度的(非线性)影响。我们没有观察到CP组对负面面部情绪的大脑反应有显著的皮质或皮质下效应。在全样本中，回归分析显示，在临床范围内，随着CP的增加，左眶前额叶皮质(OFC)的活动显著线性增加。在高CP组，显著的倒U形效应表明高CP组的左侧OFC反应再次降低。在负性情绪加工过程中，左侧OFC活动随着CP的增加而增加，并在最高CP范围内减少，这可能反映了正面控制机制的重要性，这种机制通过促进青少年更高的社会参与度和对社会内容的更好评估来抵消严重CP的后果。网上版载有补充材料，可在10.1007/s00787-021-01770-1查阅。
Conduct problems (CP) in patients with disruptive behavior disorders have been linked to impaired prefrontal processing of negative facial affect compared to controls. However, it is unknown whether associations with prefrontal activity during affective face processing hold along the CP dimension in a healthy population sample, and how subcortical processing is affected. We measured functional brain responses during negative affective face processing in 1444 healthy adolescents [M = 14.39 years (SD = 0.40), 51.5% female] from the European IMAGEN multicenter study. To determine the effects of CP, we applied a two-step approach: (a) testing matched subgroups of low versus high CP, extending into the clinical range [N = 182 per group, M = 14.44 years, (SD = 0.41), 47.3% female] using analysis of variance, and (b) considering (non)linear effects along the CP dimension in the full sample and in the high CP group using multiple regression. We observed no significant cortical or subcortical effect of CP group on brain responses to negative facial affect. In the full sample, regression analyses revealed a significant linear increase of left orbitofrontal cortex (OFC) activity with increasing CP up to the clinical range. In the high CP group, a significant inverted u-shaped effect indicated that left OFC responses decreased again in individuals with high CP. Left OFC activity during negative affective processing which is increasing with CP and decreasing in the highest CP range may reflect on the importance of frontal control mechanisms that counteract the consequences of severe CP by facilitating higher social engagement and better evaluation of social content in adolescents. The online version contains supplementary material available at 10.1007/s00787-021-01770-1.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
10.1016/j.jaac.2014.02.009
发表时间：
2014-06
影响因子：
13.3
作者：
Fairchild, Graeme;Hagan, Cindy C.;Passamonti, Luca;Walsh, Nicholas D.;Goodyer, Ian M.;Calder, Andrew J.
通讯作者：
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