The Comparison of Regional RNFL and Fundus Vasculature by OCTA in Chinese Myopia Population.
The Comparison of Regional RNFL and Fundus Vasculature by OCTA in Chinese Myopia Population.
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中国近视人群区域RNFL和眼底脉管系统OCTA比较
DOI：
10.1155/2018/3490962
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发表时间：
2018
影响因子：
1.9
通讯作者：
Jiang B
中科院分区：
文献类型：
--
作者：
Li Y;Miara H;Ouyang P;Jiang B
目的应用光学相干断层血管成像(OCTA)技术，探讨国人视网膜象限视网膜周围血管密度、视网膜神经纤维层(RNFL)厚度与近视指数的相关性。方法研究对象为−3.63 ± 0.29 D的5 6例受试者。用OCTA测量上、鼻、下、颞部四个区段的视乳头周围RNFL厚度和视网膜血管密度，并对主要结果进行相关性分析。结果上象限(r=−0.335，P=0.001)和下象限(r=−0.551，P<；0.001)视轴长度(AL)与视盘周围RNFL厚度呈负相关。与相应象限和鼻象限的等值球面(SE)呈显著正相关(r=0.339，P=0.001；r=0.379，P<；0.001；r=0.209，P=0.039)。鼻象限视网膜乳头周围血管密度与眼压呈负相关(r=−0.392，P<；0.001)，仅鼻象限与SE呈正相关(r=0.319，P=0.001)。结论AL的近视程度和延长程度与上、下象限视网膜神经纤维层厚度、鼻象限视网膜血管密度呈负相关。
Purpose To determine the correlations between peripapillary vessel density, retinal nerve fibre layer (RNFL) thickness, and myopic indices at retina quadrants with optical coherence tomography angiography (OCTA) in Chinese. Methods Fifty-six subjects with a mean spherical equivalent (MSE) of −3.63 ± 0.29 D were included. Peripapillary RNFL thickness and retinal vessel density in four sectors (superior, nasal, inferior, and temporal quadrants) were determined by OCTA, and correlations of the main outcomes were analyzed. Results Negative correlations were found between the peripapillary RNFL thickness and axial length (AL) at superior (r = −0.335, P = 0.001) and inferior (r = −0.551, P < 0.001) quadrants. There was a significant positive correlation with spherical equivalent (SE) at the corresponding quadrants as well as at the nasal quadrant (r = 0.339, P = 0.001; r = 0.379, P < 0.001; and r = 0.209, P = 0.039, resp.). Peripapillary retinal vessel density was also negatively correlated with AL at the nasal quadrant (r = −0.392, P < 0.001), and only at the nasal quadrant, there was a positive correlation between the peripapillary vessel density and SE (r = 0.319, P = 0.001). Conclusions The degree of myopia and elongation of AL were negatively correlated with peripapillary RNFL thickness at superior and inferior quadrants and with peripapillary retinal vessel density at the nasal quadrant.
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