Nutritional and metabolic status of children with autism vs. neurotypical children, and the association with autism severity.
Nutritional and metabolic status of children with autism vs. neurotypical children, and the association with autism severity.
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DOI：
10.1186/1743-7075-8-34
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发表时间：
2011-06-08
影响因子：
4.5
通讯作者：
Lee W
中科院分区：
文献类型：
--
作者：
Adams JB;Audhya T;McDonough-Means S;Rubin RA;Quig D;Geis E;Gehn E;Loresto M;Mitchell J;Atwood S;Barnhouse S;Lee W
相对代谢紊乱与发育障碍之间的关系是一个新兴的研究热点。本研究比较了自闭症儿童与神经正常儿童的营养和代谢状况，并调查了自闭症严重程度与生物标志物的可能关联。参与者是亚利桑那州5-16岁的自闭症谱系障碍儿童（n = 55），与年龄、性别和地理分布相似的非兄弟姐妹、神经典型对照组（n = 44）进行比较。在样本采集前的两个月内，两组都没有服用任何维生素/矿物质补充剂。自闭症严重程度评估使用广泛性发育障碍行为量表（PDD-BI），自闭症治疗评估量表（ATEC），和自闭症严重程度量表（SAS）。研究测量包括：维生素、维生素状态的生物标志物、矿物质、血浆氨基酸、血浆谷胱甘肽和氧化应激、甲基化、硫酸化和能量产生的生物标志物。使用t检验或Wilcoxon检验将自闭症儿童的生物标志物与对照组的生物标志物进行比较，发现以下统计学显著差异（p < 0.001）：低水平的生物素、血浆谷胱甘肽、RBC SAM、血浆尿苷、血浆ATP、RBC NADH、RBC NADPH、血浆硫酸盐（游离和总）和血浆色氨酸;还有高水平的氧化应激标志物和血浆谷氨酸。神经型对照的生物标志物水平与获得的已发表参考范围一致。在自闭症组中，临床护理中通常测量的维生素，矿物质和大多数氨基酸的平均水平在公布的参考范围内。逐步多元线性回归分析表明，几组生物标志物与所有三种自闭症严重程度量表之间存在显著关联，包括维生素（调整R2为0.25-0.57），矿物质（调整R2为0.22-0.38）和血浆氨基酸（调整R2为0.22-0.39）。自闭症组在营养和代谢状态方面有许多统计学上的显著差异，包括指示维生素不足的生物标志物，氧化应激增加，能量运输能力降低，硫酸盐化和解毒。几个生物标志物组与自闭症严重程度的变化显著相关。这些营养和代谢差异通常与其他已发表的结果一致，并且可能适合于营养补充。研究调查治疗及其与自闭症的共病和病因的关系是必要的。
The relationship between relative metabolic disturbances and developmental disorders is an emerging research focus. This study compares the nutritional and metabolic status of children with autism with that of neurotypical children and investigates the possible association of autism severity with biomarkers. Participants were children ages 5-16 years in Arizona with Autistic Spectrum Disorder (n = 55) compared with non-sibling, neurotypical controls (n = 44) of similar age, gender and geographical distribution. Neither group had taken any vitamin/mineral supplements in the two months prior to sample collection. Autism severity was assessed using the Pervasive Development Disorder Behavior Inventory (PDD-BI), Autism Treatment Evaluation Checklist (ATEC), and Severity of Autism Scale (SAS). Study measurements included: vitamins, biomarkers of vitamin status, minerals, plasma amino acids, plasma glutathione, and biomarkers of oxidative stress, methylation, sulfation and energy production. Biomarkers of children with autism compared to those of controls using a t-test or Wilcoxon test found the following statistically significant differences (p < 0.001): Low levels of biotin, plasma glutathione, RBC SAM, plasma uridine, plasma ATP, RBC NADH, RBC NADPH, plasma sulfate (free and total), and plasma tryptophan; also high levels of oxidative stress markers and plasma glutamate. Levels of biomarkers for the neurotypical controls were in good agreement with accessed published reference ranges. In the Autism group, mean levels of vitamins, minerals, and most amino acids commonly measured in clinical care were within published reference ranges. A stepwise, multiple linear regression analysis demonstrated significant associations between several groups of biomarkers with all three autism severity scales, including vitamins (adjusted R2 of 0.25-0.57), minerals (adj. R2 of 0.22-0.38), and plasma amino acids (adj. R2 of 0.22-0.39). The autism group had many statistically significant differences in their nutritional and metabolic status, including biomarkers indicative of vitamin insufficiency, increased oxidative stress, reduced capacity for energy transport, sulfation and detoxification. Several of the biomarker groups were significantly associated with variations in the severity of autism. These nutritional and metabolic differences are generally in agreement with other published results and are likely amenable to nutritional supplementation. Research investigating treatment and its relationship to the co-morbidities and etiology of autism is warranted.
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影响因子：
2.8
作者：
Al-Gadani, Y.;EI-Ansary, A.;Al-Ayadhi, L.
通讯作者：
Al-Ayadhi, L.
影响因子：
2.6
作者：
Adams, JB;George, F;Audhya, T
通讯作者：
Audhya, T
DOI：
10.1080/15287390601172080
发表时间：
2007-01-01
影响因子：
2.6
作者：
Adams, James B.;Romdalvik, Jane;Legator, Marvin S.
通讯作者：
Legator, Marvin S.
影响因子：
3.9
作者：
Adams, JB;Holloway, CE;Quig, D
通讯作者：
Quig, D
影响因子：
4.7
作者：
Cannell, John Jacob
通讯作者：
Cannell, John Jacob