Determinants of (18)F-NaF uptake in femoral arteries in patients with type 2 diabetes mellitus.
Determinants of (18)F-NaF uptake in femoral arteries in patients with type 2 diabetes mellitus.
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DOI：
10.1007/s12350-020-02099-z
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Beulens JW
中科院分区：
文献类型：
--
作者：
Takx RAP;van Asperen R;Bartstra JW;Zwakenberg SR;Wolterink JM;Celeng C;de Jong PA;Beulens JW
本研究的目的是研究作为2型糖尿病和动脉疾病史患者动脉钙化标志的18F-NaF在股动脉摄取的潜在决定因素。该研究包括一项随机对照试验的参与者，以调查维生素K2 （NCT02839044）的效果。在这个预先指定的分析中，患有2型糖尿病和已知动脉疾病的受试者进行了全身18F-NaF PET/CT检查。用两股浅动脉SUVmax均值除以上腔静脉（SVC） SUVmax均值计算靶本比（TBR），并在CT上测量钙质量。18F-NaF TBR与心血管危险因素之间的关系通过校正年龄和性别的单变量和多变量线性回归进行了研究。共68例患者（平均年龄69±8岁，男性52岁）行18F-NaF PET/CT检查。调整后CT钙质量、总胆固醇和HbA1c升高与18F-NaF TBR升高相关。该研究表明，几种可改变的心血管危险因素（总胆固醇、甘油三酯、HbA1c）与2型糖尿病患者股骨18F-NaF示指示剂摄取相关。本文的在线版本（10.1007/s12350-020-02099-z）包含补充资料，仅供授权用户使用。
The goal of this study was to investigate the potential determinants of 18F-NaF uptake in femoral arteries as a marker of arterial calcification in patients with type 2 diabetes and a history of arterial disease. The study consisted of participants of a randomized controlled trial to investigate the effect of vitamin K2 (NCT02839044). In this prespecified analysis, subjects with type 2 diabetes and known arterial disease underwent full body 18F-NaF PET/CT. Target-to-background ratio (TBR) was calculated by dividing the mean SUVmax from both superficial femoral arteries by the SUVmean in the superior vena cava (SVC) and calcium mass was measured on CT. The association between 18F-NaF TBR and cardiovascular risk factors was investigated using uni- and multivariate linear regression corrected for age and sex. In total, 68 patients (mean age: 69 ± 8 years; male: 52) underwent 18F-NaF PET/CT. Higher CT calcium mass, total cholesterol, and HbA1c were associated with higher 18F-NaF TBR after adjusting. This study shows that several modifiable cardiovascular risk factors (total cholesterol, triglycerides, HbA1c) are associated with femoral 18F-NaF tracer uptake in patients with type 2 diabetes. The online version of this article (10.1007/s12350-020-02099-z) contains supplementary material, which is available to authorized users.
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影响因子：
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