Gut Microbiota Composition Is Related to Cardiorespiratory Fitness in Healthy Young Adults.
Gut Microbiota Composition Is Related to Cardiorespiratory Fitness in Healthy Young Adults.
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肠道菌群组成与健康的年轻人的心肺适应性有关。
DOI：
10.1123/ijsnem.2018-0024
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发表时间：
2019-05-01
影响因子：
2.5
通讯作者：
Bagley JR
中科院分区：
文献类型：
--
作者：
Durk RP;Castillo E;Márquez-Magaña L;Grosicki GJ;Bolter ND;Lee CM;Bagley JR
驻留在人类胃肠道（GI）中的细菌与其宿主具有共生关系。动物模型已经证明了运动和肠道微生物群组成之间的关系。这是第一项探索自由生活环境中健康年轻人心肺适能（最大耗氧量，VO 2 max）与相对肠道微生物群组成[厚壁菌门与拟杆菌门比率（F/B）]之间关系的研究。20名男性和18名女性（25.7±2.2岁）自愿参加本研究，他们在过去6个月内未服用抗生素。VO 2 max采用限幅分级跑台试验测量。通过使用定量聚合酶链反应（qPCR）分析从粪便样品提取的DNA来确定相对微生物群组成，所述定量聚合酶链反应特异性地测量厚壁菌门和拟杆菌门中发现的靶基因（16 s RNA）的量。F/B和潜在相关的饮食、人体测量和健身变量之间的关系采用相关分析和适当的Bonferroni调整进行评估（p<0.004）。所有参与者的平均F/B比值为0.94±0.03。F/B比值与最大摄氧量显著相关（r=0.48，p<0.003），但与其他健身、营养摄入或人体测量变量无关（p>0.004）。VO 2 max解释了个体相对肠道细菌变异的约22%，如F/B比所确定的。这些数据支持动物研究结果，证明了相对人类肠道微生物群组成与健康年轻人的心肺健康之间的关系。胃肠道细菌在调节无数生理过程中不可或缺，关于运动和营养对肠道微生物组成的影响的更深入了解可能有助于指导促进人类健康的治疗。
Bacteria residing in the human gastrointestinal (GI) tract has a symbiotic relationship with its host. Animal models have demonstrated a relationship between exercise and gut microbiota composition. This was the first study to explore the relationship between cardiorespiratory fitness (maximal oxygen consumption, VO2max) and relative gut microbiota composition [Firmicutes to Bacteroidetes ratio (F/B)] in healthy young adults in a free-living environment. Twenty males and 18 females (25.7±2.2 y), who did not take antibiotics in the last 6 months, volunteered for this study. VO2max was measured using a symptom-limited graded treadmill test. Relative microbiota composition was determined by analyzing DNA extracted from stool samples using Quantitative Polymerase Chain Reaction (qPCR) that specifically measured the quantity of a target gene (16s RNA) found in Firmicutes and Bacteroidetes. Relationships between F/B and potentially related dietary, anthropometric, and fitness variables were assessed using correlation analyses with appropriate Bonferroni adjustment (p<0.004). Average F/B ratio in all participants was 0.94±0.03. F/B ratio was significantly correlated to VO2max (r=0.48, p<0.003) but, no other fitness, nutritional intake, or anthropometric variables (p>0.004). VO2max explained ~22% of the variance of an individual’s relative gut bacteria as determined by F/B ratio. These data support animal findings, demonstrating a relationship between relative human gut microbiota composition and cardiorespiratory fitness in healthy young adults. GI bacteria is integral in regulating a myriad of physiological processes, and greater insight regarding ramifications of exercise and nutrition on gut microbial composition may help guide therapies to promote human health.
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DOI：
10.1097/mco.0000000000000209
发表时间：
2015-09
影响因子：
3.1
作者：
Murphy EA;Velazquez KT;Herbert KM
通讯作者：
Herbert KM
影响因子：
15.5
作者：
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DOI：
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发表时间：
2013-02-01
期刊：
Science (New York, N.Y.)
影响因子：
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作者：
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Gordon JI
影响因子：
2.1
作者：
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通讯作者：
Licht, Tine Rask
DOI：
10.1249/mss.0000000000001495
发表时间：
2018-04-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
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作者：
Allen, Jacob M.;Mailing, Lucy J.;Woods, Jeffrey A.
通讯作者：
Woods, Jeffrey A.