Spatial memory deficits in a virtual reality eight-arm radial maze in schizophrenia.
Spatial memory deficits in a virtual reality eight-arm radial maze in schizophrenia.
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DOI：
10.1016/j.schres.2011.11.014
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发表时间：
2012-03
影响因子：
4.5
通讯作者：
Rowland, Laura M.
中科院分区：
文献类型：
--
作者：
Spieker, Elena A.;Astur, Robert S.;West, Jeffrey T.;Griego, Jacqueline A.;Rowland, Laura M.
学习和记忆障碍存在于精神分裂症（SZ）的整个病程中，并预测心理社会功能。前额叶和海马功能异常被认为是导致SZ缺陷的原因。桡臂迷宫（RAM）是一种依赖于完整的前额叶和海马功能的啮齿动物空间学习和记忆测试。本研究的目的是利用虚拟内存来研究SZ的空间学习。33名SZ受试者和39名健康对照（HC）进行了10次虚拟RAM任务试验。实验对象试图学习取回四个分别放在不同手臂上的奖励。正如预期的那样，SZ组的被试比HC组使用更多的时间和更远的距离来检索奖励，犯更多的参考（RM）和工作记忆（WM）错误，并且检索到更少的奖励。值得注意的是，SZ组确实学习了，但没有达到HC的水平。SZ组的RM误差减少了，而WM误差没有。精神症状严重程度与迷宫表现无显著关系。据我们所知，在SZ使用虚拟8臂径向迷宫任务来评估空间学习是新颖的。SZ的虚拟RAM性能受损与SZ动物模型的RAM性能研究一致。结果进一步支持脑区WM和RM缺陷背后的前额叶和海马功能受损。虚拟RAM任务可以为SZ新药治疗的临床前和临床研究搭建桥梁。
Learning and memory impairments are present in schizophrenia (SZ) throughout the illness course and predict psychosocial function. Abnormalities in prefrontal and hippocampal function are thought to contribute to SZ deficits. The radial arm maze (RAM) is a test of spatial learning and memory in rodents that relies on intact prefrontal and hippocampal function. The goal of the present study was to investigate spatial learning in SZ using a virtual RAM. Thirty-three subjects with SZ and thirty-nine healthy controls (HC) performed ten trials of a virtual RAM task. Subjects attempted to learn to retrieve four rewards each located in separate arms. As expected, subjects with SZ used more time and traveled more distance to retrieve rewards, made more reference (RM) and working memory (WM) errors, and retrieved fewer rewards than HC. It is important to note that the SZ group did learn but did not reach the level of HC. Whereas RM errors decreased across trials in the SZ group, WM errors did not. There were no significant relationships between psychiatric symptom severity and maze performance. To our knowledge, use of a virtual 8-arm radial maze task in SZ to assess spatial learning is novel. Impaired virtual RAM performance in SZ is consistent with studies that examined RAM performance in animal models of SZ. Results provide further support for compromised prefrontal and hippocampal function underlying WM and RM deficits in SZ. The virtual RAM task could help bridge preclinical and clinical research for testing novel drug treatments of SZ.
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影响因子：
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作者：
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