The nuts and bolts of low-level laser (light) therapy.

The nuts and bolts of low-level laser (light) therapy.
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DOI:
10.1007/s10439-011-0454-7
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发表时间:
2012-02
影响因子:
3.8
通讯作者:
Hamblin, Michael R.
Hamblin, Michael R.
中科院分区:
工程技术2区
文献类型:
--
作者:
Chung, Hoon;Dai, Tianhong;Sharma, Sulbha K.;Huang, Ying-Ying;Carroll, James D.;Hamblin, Michael R.

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在20世纪60年代发现激光后不久,人们意识到激光疗法有可能改善伤口愈合,减轻疼痛,炎症和肿胀。近年来,有时被称为光生物调节的领域已经扩大到包括发光二极管和其他光源,现在使用的波长范围包括许多红色和近红外线。术语“低水平激光治疗”或LLLT已被广泛认可,并暗示存在双相剂量反应或Arrhythm-Schulz曲线。本次审查将涵盖LLLT在细胞和组织水平上的作用机制,并将总结各种光源和在临床实践中采用的剂量学原理。将总结LLLT可以受益的疾病,损伤和病症的范围,重点是那些已经报告的随机对照临床试验。严重危及生命的疾病,如中风,心脏病发作,脊髓损伤和创伤性脑损伤可能很快就会适合LLLT治疗。
Soon after the discovery of lasers in the 1960s it was realized that laser therapy had the potential to improve wound healing and reduce pain, inflammation and swelling. In recent years the field sometimes known as photobiomodulation has broadened to include light-emitting diodes and other light sources, and the range of wavelengths used now includes many in the red and near infrared. The term “low level laser therapy” or LLLT has become widely recognized and implies the existence of the biphasic dose response or the Arndt-Schulz curve. This review will cover the mechanisms of action of LLLT at a cellular and at a tissular level and will summarize the various light sources and principles of dosimetry that are employed in clinical practice. The range of diseases, injuries, and conditions that can be benefited by LLLT will be summarized with an emphasis on those that have reported randomized controlled clinical trials. Serious life-threatening diseases such as stroke, heart attack, spinal cord injury, and traumatic brain injury may soon be amenable to LLLT therapy.
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