Choroidal Thickness and Choroidal Vessel Density in Nonexudative Age-Related Macular Degeneration Using Swept-Source Optical Coherence Tomography Imaging.
Choroidal Thickness and Choroidal Vessel Density in Nonexudative Age-Related Macular Degeneration Using Swept-Source Optical Coherence Tomography Imaging.
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DOI：
10.1167/iovs.16-20161
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发表时间：
2016-11-01
影响因子：
4.4
通讯作者：
Rosenfeld PJ
中科院分区：
文献类型：
--
作者：
Zheng F;Gregori G;Schaal KB;Legarreta AD;Miller AR;Roisman L;Feuer WJ;Rosenfeld PJ
分析非渗出性AMD眼脉络膜厚度与脉络膜血管分布的关系。使用原型100-kHz扫频源（SS）光学相干断层扫描（OCT）仪器（Carl Zeiss Meditec，都柏林，CA，美国）以1050 nm的中心波长对诊断为非渗出性AMD的眼睛进行成像。我们使用OCT立方体扫描模式，包括在12 × 12 mm视网膜区域上进行512 × 512 A扫描。根据是否存在网状假性玻璃疣（RPD），将眼睛分为两组。使用自动算法分割所有扫描。此外，从两组中的每一组中随机选择五只眼睛进行手动分割。从合适的OCT脉络膜厚片生成二元脉络膜血管图，并使用以中央凹为中心的早期治疗糖尿病视网膜病变研究样目标分析大脉络膜血管密度与脉络膜厚度之间的关系。每组入组25只眼。自动算法产生了准确的脉络膜厚度图，手动和自动分割之间的平均差异为13.7 μm。在两组中，脉络膜厚度和脉络膜血管密度之间存在显著且稳定的相关性。RPD眼的平均脉络膜厚度和血管密度均显著降低。我们的全自动脉络膜分割算法能够在大范围内捕获脉络膜厚度的不同模式。在我们的样本中，脉络膜厚度与脉络膜大血管的密度有明确的关系，无论是否存在RPD。
To analyze the relationship between choroidal thickness and the distribution of choroidal blood vessels in eyes with nonexudative AMD. Eyes with a diagnosis of nonexudative AMD were imaged using a prototype 100-kHz swept-source (SS) optical coherence tomography (OCT) instrument (Carl Zeiss Meditec, Dublin, CA, USA) with a central wavelength of 1050 nm. We used an OCT cube scan pattern consisting of 512 × 512 A-scans over a 12 × 12 mm retinal area. The eyes were partitioned into two groups based on the presence or absence of reticular pseudodrusen (RPD). All scans were segmented using an automated algorithm. In addition, five eyes from each of the two groups were randomly chosen for manual segmentation. Binary choroidal vessels maps were generated from suitable OCT choroidal slabs, and the relationship between the density of large choroidal vessels and choroidal thickness was analyzed using an Early Treatment Diabetic Retinopathy Study–like target centered on the fovea. Twenty-five eyes were enrolled in each group. The automated algorithm produced accurate choroidal thickness maps with an average difference between the manual and automated segmentations of 13.7 μm. There was a significant and stable correlation between choroidal thickness and choroidal vessel density across the two groups. Both average choroidal thickness and vessel density were significantly lower in eyes with RPD. Our fully automated choroidal segmentation algorithm was able to capture the different patterns of choroidal thickness over a wide area. Choroidal thickness has a clear relationship with the density of large choroid vessels in our sample, irrespective of the presence or absence of RPD.
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影响因子：
13.7
作者：
Branchini LA;Adhi M;Regatieri CV;Nandakumar N;Liu JJ;Laver N;Fujimoto JG;Duker JS
通讯作者：
Duker JS
影响因子：
3.7
作者：
Grewal DS;Chou J;Rollins SD;Fawzi AA
通讯作者：
Fawzi AA
影响因子：
17.8
作者：
Ferrara, Daniela;Waheed, Nadia K.;Duker, Jay S.
通讯作者：
Duker, Jay S.
中国健康受试者的视乳头周围脉络膜厚度
影响因子：
2
作者：
Huang W;Wang W;Zhou M;Chen S;Gao X;Fan Q;Ding X;Zhang X
通讯作者：
Zhang X
DOI：
10.1097/iae.0b013e3181be0a83
发表时间：
2009-11-01
影响因子：
3.3
作者：
Imamura, Yutaka;Fujiwara, Takamitsu;Spaide, Richard F.
通讯作者：
Spaide, Richard F.