Visual evoked feedforward-feedback traveling waves organize neural activity across the cortical hierarchy in mice.
Visual evoked feedforward-feedback traveling waves organize neural activity across the cortical hierarchy in mice.
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DOI：
10.1038/s41467-022-32378-x
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发表时间：
2022-08-13
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
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作者：
感觉处理分布在通过前馈和反馈信号相互作用的许多大脑区域中。神经元振荡已被证明介导皮层间的前馈和反馈相互作用。然而，大量这种振荡的宏观结构仍然不清楚。在这里，我们表明，简单的视觉刺激可靠地唤起两个行波的空间波长，覆盖了清醒小鼠的大脑半球。30-50 Hz前馈波起源于初级视皮层（V1），并向吻侧传播，而3-6 Hz反馈波起源于联合皮层，并向尾侧传播。反馈波的相位调制前馈波的振幅和V1和顶叶皮层之间的放电。总之，这些结果提供了直接的实验证据，视觉诱发的行波渗透通过大脑皮层和协调神经元活动广泛分布的网络介导的视觉处理。处理感官刺激需要广泛分布在许多遥远的皮层部位的神经元的协调激活，但目前尚不清楚这种协调是如何在大脑中完成的。在这里，作者表明，视觉刺激可靠地唤起了活动的行波，这些活动渗透到皮层，并协调了初级视觉和联合皮层的神经元放电。
Sensory processing is distributed among many brain regions that interact via feedforward and feedback signaling. Neuronal oscillations have been shown to mediate intercortical feedforward and feedback interactions. Yet, the macroscopic structure of the multitude of such oscillations remains unclear. Here, we show that simple visual stimuli reliably evoke two traveling waves with spatial wavelengths that cover much of the cerebral hemisphere in awake mice. 30-50 Hz feedforward waves arise in primary visual cortex (V1) and propagate rostrally, while 3-6 Hz feedback waves originate in the association cortex and flow caudally. The phase of the feedback wave modulates the amplitude of the feedforward wave and synchronizes firing between V1 and parietal cortex. Altogether, these results provide direct experimental evidence that visual evoked traveling waves percolate through the cerebral cortex and coordinate neuronal activity across broadly distributed networks mediating visual processing. Processing sensory stimuli requires coordinated activation of neurons broadly distributed across many distant cortical sites, yet it is not clear how this coordination is accomplished in the brain. Here, the authors show that visual stimuli reliably evoke traveling waves of activity that percolate through the cortex and orchestrate neuronal firing across primary visual and association cortices.
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影响因子：
16.2
作者：
Bosman CA;Schoffelen JM;Brunet N;Oostenveld R;Bastos AM;Womelsdorf T;Rubehn B;Stieglitz T;De Weerd P;Fries P
通讯作者：
Fries P
细胞外田地和电流的起源-EEG，ECOG，LFP和尖峰。
DOI：
10.1038/nrn3241
发表时间：
2012-05-18
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Buzsáki G;Anastassiou CA;Koch C
通讯作者：
Koch C
影响因子：
7.7
作者：
D'Souza, Rinaldo David;Meier, Andrew Max;Burkhalter, Andreas
通讯作者：
Burkhalter, Andreas
影响因子：
7.7
作者：
Denman, Daniel J.;Luviano, Jennifer A.;Reid, R. Clay
通讯作者：
Reid, R. Clay
DOI：
10.1523/jneurosci.2699-08.2008
发表时间：
2008-10-01
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bollimunta A;Chen Y;Schroeder CE;Ding M
通讯作者：
Ding M