Prenatal exposure to organophosphate pesticides and brain morphology and white matter microstructure in preadolescents.
Prenatal exposure to organophosphate pesticides and brain morphology and white matter microstructure in preadolescents.
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DOI：
10.1016/j.envres.2020.110047
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发表时间：
2020-12
影响因子：
8.3
通讯作者：
Guxens M
中科院分区：
文献类型：
--
作者：
van den Dries MA;Lamballais S;El Marroun H;Pronk A;Spaan S;Ferguson KK;Longnecker MP;Tiemeier H;Guxens M
在人类和动物模型中，产前暴露于有机磷（OP）农药与神经发育受损有关。然而，这些关联背后的大脑结构改变存在很多不确定性。本研究的目的是确定是否母亲的OP农药代谢物浓度在尿液中重复测量妊娠期间与脑形态和白色物质的显微结构在518个9-12岁的青春期前。数据来自518对参与R世代研究的母子，这是一项来自荷兰鹿特丹的基于人口的出生队列研究。在妊娠早期、中期和晚期采集母体尿液，测定6种二烷基磷酸盐（DAP）的浓度，包括3种二甲基（DM）和3种二乙基（DE）烷基磷酸盐代谢物。在儿童9-12岁时，进行磁共振成像以获得局部脑体积和基于表面的皮质厚度和表面积的T1加权图像，以及通过分数各向异性（FA）和平均扩散率（MD）测量白色物质微观结构的扩散张量图像。线性回归模型适用于整个妊娠期的平均产前暴露。DE和DM代谢物浓度与局部脑体积、皮质厚度和皮质表面积无关。然而，在整个妊娠期间，平均DM代谢物浓度增加10倍与FA降低（B=−1.00，95%CI=−1.80，−0.20）和MD升高（B=0.13，95%CI=0.04，0.21）相关。DE浓度也存在类似的相关性。这项研究提供了第一个证据，表明OP农药可能会改变儿童正常的白色物质微观结构，这可能会对正常的神经发育产生影响。未观察到与结构性脑形态（包括局部脑体积、皮质厚度或皮质表面积）的相关性。
Prenatal exposure to organophosphate (OP) pesticides associate with impaired neurodevelopment in humans and animal models. However, much uncertainty exists about the brain structural alterations underlying these associations. The objective of this study was to determine whether maternal OP pesticide metabolite concentrations in urine repeatedly measured during gestation are associated with brain morphology and white matter microstructure in 518 preadolescents aged 9–12 years. Data came from 518 mother—child pairs participating in the Generation R study, a population-based birth cohort from Rotterdam, the Netherlands. Maternal urine concentrations were determined for 6 dialkylphosphates (DAPs)including 3 dimethyl(DM)and 3 diethyl (DE) alkyl phosphate metabolites, collected at early, mid, and late pregnancy. At child’s age 9–12 years, magnetic resonance imaging was performed to obtain T1-weighted images for regional brain volumes and surface-based cortical thickness and surface area, and diffusion tensor images to measure white matter microstructure through fractional anisotropy (FA) and mean diffusivity (MD). Linear regression models were fit for the averaged prenatal exposure across pregnancy. DE and DM metabolite concentrations were not associated with regional brain volumes, cortical thickness, and cortical surface area. However, a 10-fold increase in averaged DM metabolite concentrations across pregnancy was associated with lower FA (B=−1.00, 95%CI=−1.80, −0.20) and higher MD (B=0.13, 95%CI=0.04, 0.21). Similar associations were observed for DE concentrations. This study provides the first evidence that OP pesticides may alter normal white matter microstructure in children, which could have consequences for normal neurodevelopment. No associations were observed with structural brain morphology, including regional brain volumes, cortical thickness, or cortical surface area.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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