Pulse wave velocity and central aortic pressure in systolic blood pressure intervention trial participants.
Pulse wave velocity and central aortic pressure in systolic blood pressure intervention trial participants.
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DOI：
10.1371/journal.pone.0203305
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Chonchol M
中科院分区：
文献类型：
--
作者：
Supiano MA;Lovato L;Ambrosius WT;Bates J;Beddhu S;Drawz P;Dwyer JP;Hamburg NM;Kitzman D;Lash J;Lustigova E;Miracle CM;Oparil S;Raj DS;Weiner DE;Taylor A;Vita JA;Yunis R;Chertow GM;Chonchol M
动脉僵硬度（通常评估为主动脉脉搏波速度（PWV））和中心血压水平可能是心血管疾病（CVD）风险的指标。这项对收缩压干预试验（SPRINT）的辅助研究获得了PWV和中心收缩压（C-SBP）的基线评估（随机化时），以：1）表征SPRINT队列中的这些血管测量值，2）检验PWV和C-SBP与葡萄糖稳态和慢性肾脏疾病（CKD）标志物相关的假设。使用SphygmoCor® CPV器械评估颈动脉-股动脉PWV，并使用其脉搏波分析研究方案获得C-SBP。从652名参与者中获得了有效结果。SPRINT队列的平均（±SD）PWV和C-SBP分别为10.7 ± 2.7 m/s和132.0 ± 17.9 mm Hg。对PWV和C-SBP结果进行线性回归分析，调整了与葡萄糖稳态和CKD的几种标志物相关的年龄、性别和人种/种族，未发现任何显著相关性，除了PWV与尿白蛋白/肌酐比值之间存在轻微的统计学显著性和中度相关性（线性回归估计值± SE，0.001 ± 0.0006; P值0.046）。在SPRINT参与者的一个子集中，PWV显著高于血压正常者的先前研究，正如预期的那样。对于SPRINT队列中的老年组（年龄> 60岁），将PWV与高血压个体的参考人群进行比较。PWV或C-SBP与葡萄糖稳态或CKD标志物之间没有令人信服的相关性。临床试验注册：NCT 01206062。
Arterial stiffness, typically assessed as the aortic pulse wave velocity (PWV), and central blood pressure levels may be indicators of cardiovascular disease (CVD) risk. This ancillary study to the Systolic Blood Pressure Intervention Trial (SPRINT) obtained baseline assessments (at randomization) of PWV and central systolic blood pressure (C-SBP) to: 1) characterize these vascular measurements in the SPRINT cohort, and 2) test the hypotheses that PWV and C-SBP are associated with glucose homeostasis and markers of chronic kidney disease (CKD). The SphygmoCor® CPV device was used to assess carotid-femoral PWV and its pulse wave analysis study protocol was used to obtain C-SBP. Valid results were obtained from 652 participants. Mean (±SD) PWV and C-SBP for the SPRINT cohort were 10.7 ± 2.7 m/s and 132.0 ± 17.9 mm Hg respectively. Linear regression analyses for PWV and C-SBP results adjusted for age, sex, and race/ethnicity in relation to several markers of glucose homeostasis and CKD did not identify any significant associations with the exception of a marginally statistically significant and modest association between PWV and urine albumin-to-creatinine ratio (linear regression estimate ± SE, 0.001 ± 0.0006; P-value 0.046). In a subset of SPRINT participants, PWV was significantly higher than in prior studies of normotensive persons, as expected. For older age groups in the SPRINT cohort (age > 60 years), PWV was compared with a reference population of hypertensive individuals. There were no compelling associations noted between PWV or C-SBP and markers of glucose homeostasis or CKD. Clinical Trial Registration: NCT01206062.
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影响因子：
37.8
作者：
Sutton-Tyrrell, K;Najjar, SS;Newman, A
通讯作者：
Newman, A
DOI：
10.1177/1740774514537404
发表时间：
2014-10
期刊：
Clinical trials (London, England)
影响因子：
--
作者：
Ambrosius WT;Sink KM;Foy CG;Berlowitz DR;Cheung AK;Cushman WC;Fine LJ;Goff DC Jr;Johnson KC;Killeen AA;Lewis CE;Oparil S;Reboussin DM;Rocco MV;Snyder JK;Williamson JD;Wright JT Jr;Whelton PK;SPRINT Study Research Group
通讯作者：
SPRINT Study Research Group
影响因子：
4
作者：
Kim, Ye-Sung;Kim, Dae-Hyun;Lee, Ae Young
通讯作者：
Lee, Ae Young
影响因子：
4.5
作者：
Shin, Seok Joon;Kim, Yong Kyun;Chung, Sungjin;Chung, Hyun Wha;Ihm, Sang Hyun;Park, Cheol Whee;Kim, Young Ok;Song, Ho Cheol;Kim, Yong Soo;Choi, Eui-Jin
通讯作者：
Choi, Eui-Jin
影响因子：
39.3
作者：
Reference Values for Arterial Stiffness' Collaboration
通讯作者：
Reference Values for Arterial Stiffness' Collaboration