Wastewater-based epidemiology for the assessment of population exposure to chemicals: The need for integration with human biomonitoring for global One Health actions.
Wastewater-based epidemiology for the assessment of population exposure to chemicals: The need for integration with human biomonitoring for global One Health actions.
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DOI：
10.1016/j.jhazmat.2023.131009
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发表时间：
2023-05-15
影响因子：
13.6
通讯作者：
Thomas, Kevin V.
中科院分区：
文献类型：
--
作者：
Kasprzyk-Hordern, Barbara;Been, Frederic;Bijlsma, Lubertus;Brack, Werner;Castiglioni, Sara;Covaci, Adrian;Martincigh, Bice S.;Mueller, Jochen F.;van Nuijs, Alexander L. N.;Oluseyi, Temilola;Thomas, Kevin V.
关键词：
WBE 现已成为 SARS-CoV-2 监测的补充工具。在此之前，WBE 已被确立应用来评估社区非法药物的消费情况。现在正是在此基础上，并借此机会扩展 WBE，以全面评估社区接触化学压力源及其混合物的情况。 WBE 的目标是量化社区暴露，发现暴露与结果之间的关联，并触发政策、技术或社会干预策略，其总体目标是预防暴露和促进公共卫生。为了充分发挥 WBE 的潜力，需要在以下关键方面采取进一步行动：(1) 整合 WBE-HBM（人类生物监测）举措，提供全面的社区-个人多化学品暴露评估。 (2) 全球 WBE 监测活动，提供中低收入国家 (LMIC) 急需的暴露数据，并填补知识空白，特别是在中低收入国家中代表性不足的高度城市化和农村环境中。 (3) 将 WBE 与 One Health 行动相结合，以实现有效的干预。 (4) WBE 进展的新分析工具和方法的进步，使得能够选择暴露研究的生物标志物，并为复杂废水基质中的痕量多生物标志物定量提供灵敏和选择性的多残留分析。最重要的是，WBE 的进一步发展需要通过与主要利益相关者群体（政府组织、卫生当局和私营部门）的共同设计来进行。
WBE has now become a complimentary tool in SARS-CoV-2 surveillance. This was preceded by the established application of WBE to assess the consumption of illicit drugs in communities. It is now timely to build on this and take the opportunity to expand WBE to enable comprehensive assessment of community exposure to chemical stressors and their mixtures. The goal of WBE is to quantify community exposure, discover exposure-outcome associations, and trigger policy, technological or societal intervention strategies with the overarching aim of exposure prevention and public health promotion. To achieve WBE’s full potential, the following key aspects require further action: (1) Integration of WBE-HBM (human biomonitoring) initiatives that provide comprehensive community-individual multichemical exposure assessment. (2) Global WBE monitoring campaigns to provide much needed data on exposure in low- and middle-income countries (LMICs) and fill in the gaps in knowledge especially in the underrepresented highly urbanised as well as rural settings in LMICs. (3) Combining WBE with One Health actions to enable effective interventions. (4) Advancements in new analytical tools and methodologies for WBE progression to enable biomarker selection for exposure studies, and to provide sensitive and selective multiresidue analysis for trace multi-biomarker quantification in a complex wastewater matrix. Most of all, further developments of WBE needs to be undertaken by co-design with key stakeholder groups: government organisations, health authorities and private sector.
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影响因子：
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作者：
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