Different distributions of calbindin and calretinin immunostaining across the medial and dorsal divisions of the mouse medial geniculate body.
Different distributions of calbindin and calretinin immunostaining across the medial and dorsal divisions of the mouse medial geniculate body.
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DOI：
10.1016/j.heares.2009.07.009
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发表时间：
2009-11
期刊：
影响因子：
2.8
通讯作者：
Sherman, S. M.
中科院分区：
文献类型：
--
作者：
Lu, E.;Llano, D. A.;Sherman, S. M.
我们研究了Calretinin和calbindin免疫反应在小鼠内侧膝状体和邻近的板旁核内的分布。我们发现，内侧膝状体背侧部的绝大多数标记细胞仅对Calbindin呈免疫反应，而其余的标记细胞大多是双标的。仅观察到极少数Calretinin+细胞。相比之下，我们观察到在内侧膝状体的内侧分裂中，仅Calbindin+、Calretinin+和双标记细胞的比例很大。此外，在内侧膝状体内侧部、膝状体上核、脚周核和椎板内后核之间，仅有Calbindin、仅Calretinin和双标记细胞的分布没有差异。我们在内侧膝状体的腹侧部基本上没有发现Calbindin或calretinin的体细胞染色。这些数据表明，这两个非丘脑听觉核团之间存在明显的神经化学差异。此外，这些数据扩展了先前的观察结果，即内侧膝状体的内侧分裂与板层旁核团有许多相似之处。
We studied the distributions of calretinin and calbindin immunoreactivity in subdivisions of the mouse medial geniculate body and the adjacent paralaminar nuclei. We found that the vast majority of labeled cells in the dorsal division of the medial geniculate body were immunoreactive for calbindin only, whereas most of the remaining labeled cells were double-labeled. Very few calretinin+ only cells were observed. By contrast, we observed significant proportions of calbindin+ only, calretinin+ only and double-labeled cells in the medial division of the medial geniculate body. Further, the distributions of calbindin-only, calretinin-only and double-labeled cells did not differ between the medial division of the medial geniculate body, the suprageniculate nucleus, the peripeduncular nucleus and the posterior intralaminar nucleus. We found essentially no somatic staining for either calbindin or calretinin in the ventral division of the medial geniculate body. These data suggest that there are distinct neurochemical differences between the two nonlemniscal auditory thalamic nuclei. In addition, these data extend previous observations that the medial division of the medial geniculate body shares many properties with the paralaminar group of nuclei.
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