Advancement of the Infant Air-Jet Dry Powder Inhaler (DPI): Evaluation of Different Positive-Pressure Air Sources and Flow Rates.
Advancement of the Infant Air-Jet Dry Powder Inhaler (DPI): Evaluation of Different Positive-Pressure Air Sources and Flow Rates.
复制标题
婴儿喷气式干粉吸入器（DPI）的进展：不同正压气源和流速的评价。
DOI：
10.1007/s11095-021-03094-w
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发表时间：
2021-09
影响因子：
3.7
通讯作者：
Longest PW
中科院分区：
文献类型：
--
作者：
Howe C;Momin MAM;Farkas DR;Bonasera S;Hindle M;Longest PW
为了改善干粉气雾剂配方对婴儿肺部的输送，本研究建立了一个婴儿喷气平台，通过早产儿鼻-喉（NT）体外模型，探讨了不同气源、流速和肺力学对雾化性能和气溶胶输送的影响。婴儿喷气平台由一个正压气源驱动，该气源输送气溶胶并提供充分的吸入呼吸。开发了三种不同的气源，以提供高度可控的正压空气驱动（早产儿模型使用约10 mL的驱动体积）。在提供不同的流动波形形状的同时，对三个气源进行了校准，以产生相同的流量量级（Q90：流量的第90个百分位数）。多种空气喷射DPI设计与空气源相结合，并通过模型喷雾干燥赋形剂增强生长配方进行评估。与其他设计相比，D1-Single喷气DPI在所有三种气源中都具有较低的可变性，从而提高了性能。在D1-Single气源和Timer气源的测试中，将流量从4 L/min降低到1.7 L/min，气溶胶粒径略有下降，肺输送效率显著提高，达到负荷剂量的50%以上。这些结果不受下游肺力学（阻力和顺应模型）的影响。所选择的设计能够提供模型喷雾干燥配方的约50%的肺输送效率，并且不受气源的影响，从而为平台在不同环境中的部署提供了更大的灵活性。
In order to improve the delivery of dry powder aerosol formulations to the lungs of infants, this study implemented an infant air-jet platform and explored the effects of different air sources, flow rates, and pulmonary mechanics on aerosolization performance and aerosol delivery through a preterm nose-throat (NT) in vitro model. The infant air-jet platform was actuated with a positive-pressure air source that delivered the aerosol and provided a full inhalation breath. Three different air sources were developed to provide highly controllable positive-pressure air actuations (using actuation volumes of ~10 mL for the preterm model). While providing different flow waveform shapes, the three air sources were calibrated to produce the same flow rate magnitude (Q90: 90th percentile of flow rate). Multiple air-jet DPI designs were coupled with the air sources and evaluated with a model spray-dried excipient enhanced growth formulation. Compared to other designs, the D1-Single air-jet DPI provided improved performance with low variability across all three air sources. With the tested D1-Single air-jet and Timer air source, reducing the flow rate from 4 to 1.7 L/min marginally decreased the aerosol size and significantly increased the lung delivery efficiency above 50% of the loaded dose. These results were not impacted by the presence of downstream pulmonary mechanics (resistance and compliance model). The selected design was capable of providing an estimated >50% lung delivery efficiency of a model spray-dried formulation and was not influenced by the air source, thereby enabling greater flexibility for platform deployment in different environments.
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DOI：
10.1089/jamp.2019.1540
发表时间：
2019-08-29
影响因子：
3.4
作者：
Farkas, Dale;Hindle, Michael;Longest, Worth
通讯作者：
Longest, Worth
影响因子：
5.8
作者：
Behara, Srinivas R. B.;Longest, P. Worth;Farkas, Dale R.;Hindle, Michael
通讯作者：
Hindle, Michael
影响因子：
5.2
作者：
Laube, Beth L.;Sharpless, Gail;Powell, Kenneth
通讯作者：
Powell, Kenneth
影响因子：
3.1
作者：
Corcoran, Timothy E.;Saville, Al;Lo, Cecilia W.
通讯作者：
Lo, Cecilia W.
DOI：
10.1159/000084880
发表时间：
2005-01-01
期刊：
Biology of the neonate
影响因子：
--
作者：
Bhutani, Vinod K;Bowen, Frank W;Sivieri, Emidio M
通讯作者：
Sivieri, Emidio M