Plasmonic nanobubbles enhance efficacy and selectivity of chemotherapy against drug-resistant cancer cells.
Plasmonic nanobubbles enhance efficacy and selectivity of chemotherapy against drug-resistant cancer cells.
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DOI：
10.1002/adma.201103550
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发表时间：
2012-07-24
影响因子：
29.4
通讯作者：
Lapotko, Dmitri O.
中科院分区：
文献类型：
--
作者：
Lukianova-Hleb, Ekaterina Y.;Ren, Xiaoyang;Zasadzinski, Joseph A.;Wu, Xiangwei;Lapotko, Dmitri O.
口腔鳞状细胞癌（OCSCC）是世界范围内最常见的恶性肿瘤之一。[1]晚期OCSCC局部复发风险高，预后差。[2]其主要原因是1）通过手术不完全去除癌细胞，特别是当伴有微转移和具有功能或重要结构的癌细胞共定位时; 2）癌细胞的多药耐药性;以及3）放射和化学疗法的急性和长期毒性。因此，需要新的治疗策略来提供癌症治疗的细胞水平选择性和对OCSCC和其他浅表癌症的耐药细胞的高功效。NP本身[3]可以通过将光能、射频和/或磁能转化为局部加热而经由热疗破坏癌细胞。[4，5，6]然而，这种直接加热方法需要显著的NP负载，因此由于周围组织的扩散加热而限制了选择性。一种上级方法是使用NP来产生等离子体纳米气泡（PNB），即由短激光脉冲产生的瞬时蒸汽纳米气泡，其覆盖金NP。[7，8] PNB的时间和空间控制的启动和崩溃产生局部光学和机械效应，可以实现成像，[8]细胞内分子靶向，[9]局部药物或基因递送，[10]以及选择性消除细胞用于治疗，治疗诊断和显微手术。[11此外，PNB的光学和声学性质提供了用于实时引导其治疗性施用的机制。
Oral cavity squamous cell carcinoma (OCSCC) is one of the most prevalent malignancies affecting patients worldwide.[1] Advanced OCSCCs are at high risk for local recurrence and are associated with poor prognosis.[2] The major reasons for this are 1) incomplete removal of cancer cells by surgery, especially when complicated by micro metastasis and colocalization of cancer cells with functionally or cosmetically important structures; 2) multidrug resistance of cancer cells, and 3) acute and long-term toxicities of radio-and chemotherapies. Therefore, new treatment strategies are needed to provide cell level selectivity of cancer treatment and high efficacy against drug-resistant cells for OCSCC and other superficial cancers.By themselves, NPs [3] can destroy cancer cells via hyperthermia by converting optical, radiofrequency and/or magnetic energy into local heating.[4, 5, 6] However, such direct heating methods require significant NP loading, thus limiting selectivity due to the diffusive heating of surrounding tissue. A superior approach is to use NPs to generate plasmonic nanobubbles (PNB), transient vapor nanobubbles generated by short laser pulses that superheat gold NPs.[7, 8] The temporally and spatially controlled initiation and collapse of PNBs creates local optical and mechanical effects that can enable imaging,[8] intracellular molecular targeting,[9] localized drug or gene delivery,[10] and selective elimination of cells for therapeutics, theranostics and microsurgery.[11, 12] In addition, the optical and acoustical properties of PNBs provide a mechanism for real-time guidance of their therapeutic
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DOI：
10.2217/nnm.10.133
发表时间：
2011-04
期刊：
Nanomedicine (London, England)
影响因子：
--
作者：
Huang HC;Yang Y;Nanda A;Koria P;Rege K
通讯作者：
Rege K
影响因子：
10.8
作者：
Anderson, Lindsey J. E.;Hansen, Eric;Lukianova-Hleb, Ekaterina Y.;Hafner, Jason H.;Lapotko, Dmitri O.
通讯作者：
Lapotko, Dmitri O.
影响因子：
14
作者：
Lukianova-Hleb, Ekaterina Y.;Belyanin, Andrey;Kashinath, Shruti;Wu, Xiangwei;Lapotko, Dmitri O.
通讯作者：
Lapotko, Dmitri O.
影响因子：
5.5
作者：
Lapotko, Dmitri O.;Lukianova-Hleb, Ekaterina Y.;Oraevsky, Alexander A.
通讯作者：
Oraevsky, Alexander A.
影响因子：
254.7
作者：
Jemal, Ahmedin;Siegel, Rebecca;Ward, Elizabeth
通讯作者：
Ward, Elizabeth