Motor stereotypies and volumetric brain alterations in children with Autistic Disorder.
Motor stereotypies and volumetric brain alterations in children with Autistic Disorder.
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DOI：
10.1016/j.rasd.2012.07.005
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发表时间：
2013-01-01
影响因子：
2.5
通讯作者：
Herbert MR
中科院分区：
文献类型：
--
作者：
Goldman S;O'Brien LM;Filipek PA;Rapin I;Herbert MR
运动刻板印象被定义为模式化的、重复的、无目的的运动。这些带有污名化的运动行为代表了自闭症（AD）诊断的第三个核心标准的一种表现，并且被视为自闭症的潜在早期标志。此外，运动刻板印象可能是这种神经发育障碍的潜在神经生物学的有形表达。在这项研究中，我们对患有AD的学龄儿童在半结构化游戏期间记录的刻板印象进行了视频评分。我们研究了刻板印象的严重程度和持续时间对脑容量变化的影响。我们的研究结果证实，患有阿尔茨海默病的学龄儿童的脑容量平均大于同龄的正常发育儿童。然而，我们没有发现任何迹象表明大脑区域的体积差异，这些区域被认为与刻板印象的病理生理学特别相关。这一消极的发现可能表明，至少在运动刻板印象方面，功能上的改变而不是结构上的改变可能是自闭症这些破坏性运动表现的基础。
Motor stereotypies are defined as patterned, repetitive, purposeless movements. These stigmatizing motor behaviors represent one manifestation of the third core criterion for an Autistic Disorder (AD) diagnosis, and are becoming viewed as potential early markers of autism. Moreover, motor stereotypies might be a tangible expression of the underlying neurobiology of this neurodevelopmental disorder. In this study, we videoscored stereotypies recorded during semi-structured play sessions from school age children with AD. We examined the effect of severity and persistence over time of stereotypies on brain volumetric changes. Our findings confirmed that the brain volume of school age children with AD is, on average, larger than that of age-matched typically developing children. However, we have failed to detect any sign of volumetric differences in brain regions thought to be particularly linked to the pathophysiology of stereotypies. This negative finding may suggest that, at least with respect to motor stereotypies, functional rather than structural alterations might be the underpinning of these disruptive motor manifestations of autism.
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影响因子：
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通讯作者：
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