Metabolic and affective consequences of fatherhood in male California mice.
Metabolic and affective consequences of fatherhood in male California mice.
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DOI：
10.1016/j.physbeh.2017.04.010
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发表时间：
2017-08-01
影响因子：
2.9
通讯作者：
Saltzman W
中科院分区：
文献类型：
--
作者：
Zhao M;Garland T Jr;Chappell MA;Andrew JR;Saltzman W
哺乳动物的生理和情感状态可以受到社会环境和父母状态的调节。然而，在雄性帮助抚养后代的物种中，配对结合和为人父对雄性的新陈代谢和情感影响很少被探索。在这项研究中，我们测试了一种假设，即父亲和母亲一样，经历了与为人父母相关的精力消耗以及行为和情感变化(例如，抑郁和焦虑)。我们在一夫一妻、双亲的加州小鼠(加州小鼠)身上测试了这一假说。比较了来自三个生殖群体的雄性的摄食量、血糖和血脂水平、血胰岛素和瘦素水平、身体成分、疼痛敏感性和抑郁样行为：处女雄性(与另一只雄性同住)、非生育雄性(与结扎输卵管的雌性同住)和有生育能力的雄性(BM，与一只雌性和他们的第一胎同住)。我们发现生殖群体在相对睾丸质量、循环血糖、甘油三酯和胰岛素浓度、疼痛敏感度和类焦虑行为方面存在统计学上的显著差异(P<；0.007，修正后为适应性错误发现率)或名义上的显著差异(0.007<；P<；0.05)。先验对比表明，在尾部悬吊试验中，VM产生的粪便颗粒显著多于BM，血糖水平显著高于NB，平均睾丸质量显著低于NB和BM。先验对比也表明，VM名义上比NB有更长的疼痛反应潜伏期，并且VM名义上比NB有更高的胰岛素水平。对于有繁殖能力的雄性，产仔数(一到三只)名义上是体重、食物消耗量、脂肪质量和血浆瘦素浓度的显著正向预测因子。这些结果表明，与雌性和/或父亲的同居影响了加州雄性小鼠的几个代谢、形态和情感指标。总体而言，我们在繁殖雄性中观察到的变化很小，但长期繁殖的雄性和/或在更具挑战性的环境条件下可能会产生更大的影响。
Physiological and affective condition can be modulated by the social environment and parental state in mammals. However, in species in which males assist with rearing offspring, the metabolic and affective effects of pair bonding and fatherhood on males have rarely been explored. In this study we tested the hypothesis that fathers, like mothers, experience energetic costs as well as behavioral and affective changes (e.g., depression; anxiety) associated with parenthood. We tested this hypothesis in the monogamous, biparental California mouse (Peromyscus californicus). Food intake, blood glucose and lipid levels, blood insulin and leptin levels, body composition, pain sensitivity, and depression-like behavior were compared in males from three reproductive groups: virgin males (VM, housed with another male), non-breeding males (NB, housed with a tubally ligated female), and breeding males (BM, housed with a female and their first litter). We found statistically significant (P < 0.007, when modified for Adaptive False Discovery Rate) or nominally significant (0.007 < P < 0.05) differences among reproductive groups in relative testis mass, circulating glucose, triglyceride, and insulin concentrations, pain sensitivity, and anxiety-like behaviors. A priori contrasts indicated that VM produced significantly more fecal pellets than BM in the tail-suspension test, had significantly higher glucose levels than NB, and had significantly lower average testis masses than did NB and BM. A priori contrasts also indicated that VM had a nominally longer latency to the pain response than NB and that VM had nominally higher insulin levels than did NB. For breeding males, litter size (one to three pups) was a nominally significant positive predictor of body mass, food consumption, fat mass, and plasma leptin concentration. These results indicate that cohabitation with a female and/or fatherhood influences several metabolic, morphological, and affective measures in California mouse males. Overall, the changes we observed in breeding males were minor, but stronger effects might occur in long-term breeding males and/or under more challenging environmental conditions.
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DOI：
10.1016/s0091-6773(74)90305-8
发表时间：
1974-01-01
期刊：
BEHAVIORAL BIOLOGY
影响因子：
--
作者：
DUDLEY, D
通讯作者：
DUDLEY, D
影响因子：
4
作者：
Borai A;Livingstone C;Kaddam I;Ferns G
通讯作者：
Ferns G
DOI：
10.1016/j.jsbmb.2007.09.001
发表时间：
2008-02-01
影响因子：
4.1
作者：
Blouin, Karine;Boivin, Ariane;Tchernof, Andre
通讯作者：
Tchernof, Andre
影响因子：
9.8
作者：
CEFALU, WT;WANG, ZQ;ANDERSON, R
通讯作者：
ANDERSON, R
影响因子：
3.5
作者：
de Jong, Trynke R.;Chauke, Miyetani;Saltzman, Wendy
通讯作者：
Saltzman, Wendy