Multispectral autofluorescence dermoscope for skin lesion assessment.
Multispectral autofluorescence dermoscope for skin lesion assessment.
复制标题
DOI：
10.1016/j.pdpdt.2020.101704
复制
发表时间：
2020-06
影响因子：
3.3
通讯作者：
Kurachi C
中科院分区：
文献类型：
--
作者：
Romano RA;Teixeira Rosa RG;Salvio AG;Jo JA;Kurachi C
基底细胞癌（BCC）是最常见的皮肤癌类型。基底细胞癌病变的诊断和边缘评估是基于临床和皮肤镜评估，这在很大程度上取决于医生的专业知识和培训。由于基底细胞癌经常与某些常见的良性病变相混淆，并且常常与周围的健康组织难以区分，因此诊断不足率很高。在本研究中，一个多光谱荧光寿命成像（FLIm）皮肤镜系统，设计用于成像和分析皮肤组织的自发荧光发射，被用来成像38例诊断为结节性BCC（nBCC）病变，使用临床上可接受的水平的激发光曝光。使用该系统，使用三个发射带：390±20 nm、452±22 nm和>496 nm同时成像皮肤自发荧光，分别优先靶向胶原蛋白、NADH和FAD自发荧光。基于FLIm特征的统计分类器用于区分BCC和健康组织，表现出良好的性能（ROC曲线下面积为0.82）。本研究证明了临床上进行多光谱内源性FLIm皮肤镜检查的可行性，提供了基线结果，表明该技术作为图像引导工具在手术病灶切除期间改善nBCC描绘的潜力。
Basal cell carcinoma (BCC) is the most common type of skin cancer. Diagnosis and edge assessment of BCC lesions are based on clinical and dermoscopy evaluation, which are strongly dependent on the expertise and training of the physician. There is a high rate of underdiagnosis because BCC is frequently confused with certain common benign lesions and is often indistinguishable from the surrounding healthy tissue. In the present study, a multispectral fluorescence lifetime imaging (FLIm) dermoscopy system, designed for imaging and analyzing the autofluorescence emission of skin tissue, was used to image thirty-eight patients with diagnosed nodular BCC (nBCC) lesions, using clinically acceptable levels of excitation light exposure. With this system, skin autofluorescence was imaged simultaneously using three emission bands: 390±20 nm, 452±22 nm, and >496 nm, preferentially targeting collagen, NADH, and FAD autofluorescence, respectively. Statistical classifiers based on FLIm features developed to discriminate BCC from healthy tissue showed promising performance (ROC area-under-the-curve of 0.82). This study demonstrates the feasibility of clinically performing multispectral endogenous FLIm dermoscopy providing baseline results indicating the potential of this technology as an image-guided tool to improve the delineation of nBCC during surgical lesion resection.
登录
查看更多内容
影响因子：
3.4
作者：
McGinty J;Galletly NP;Dunsby C;Munro I;Elson DS;Requejo-Isidro J;Cohen P;Ahmad R;Forsyth A;Thillainayagam AV;Neil MA;French PM;Stamp GW
通讯作者：
Stamp GW
影响因子：
3.4
作者：
Patalay R;Talbot C;Alexandrov Y;Munro I;Neil MA;König K;French PM;Chu A;Stamp GW;Dunsby C
通讯作者：
Dunsby C
影响因子：
3.6
作者：
Cheng S;Rico-Jimenez JJ;Jabbour J;Malik B;Maitland KC;Wright J;Cheng YS;Jo JA
通讯作者：
Jo JA
基于荧光寿命成像显微镜的非黑色素瘤皮肤病变支持向量机分类
影响因子：
7.4
作者：
Chen, Bingling;Lu, Yuan;Qu, Junle
通讯作者：
Qu, Junle
影响因子：
7.2
作者：
Glas, AS;Lijmer, JG;Bossuyt, PMM
通讯作者：
Bossuyt, PMM