Effect of Iron and Folic Acid Supplementation on the Level of Essential and Toxic Elements in Young Women.
Effect of Iron and Folic Acid Supplementation on the Level of Essential and Toxic Elements in Young Women.
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DOI：
10.3390/ijerph18031360
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发表时间：
2021-02-02
影响因子：
--
通讯作者：
Baralkiewicz D
中科院分区：
文献类型：
--
作者：
Suliburska J;Chmurzynska A;Kocylowski R;Skrypnik K;Radziejewska A;Baralkiewicz D
虽然同时补充铁和叶酸是合理的，但这些微量营养素和其他元素之间的潜在相互作用知之甚少。在这项研究中，我们的目的是调查铁和叶酸补充剂对微量营养素缺乏的年轻女性血清中选定的必需和有毒元素的水平的影响。共有40名妇女参加了这项研究，并分为两组：研究组（n = 23）（铁和叶酸缺乏）和对照组（n = 17）。研究组接受铁和叶酸补充剂3个月。在基线和研究期结束后采集血样。女性完成了3天的食物摄入记录。我们计算了所有参与者的身体质量指数（BMI）。分析全血中的细胞形态，并测定血清中的生化参数。通过电感耦合等离子体质谱法（ICP-MS）测定血清中的元素。根据我们的研究结果，在研究组的情况下，补充铁和叶酸恢复了它们的水平;然而，它导致锌，钙和镁的水平显着下降。在对照组的情况下，在研究期结束时，铁的水平显著下降。有趣的是，两组中砷和钒的水平都有所增加。总之，同时补充铁和叶酸会损害育龄妇女的锌、钙和镁水平。
Although simultaneous supplementation of iron and folic acid is justified, the potential interactions between these micronutrients and other elements are poorly known. In this study, we aimed to investigate the effect of iron and folic acid supplementation on the levels of selected essential and toxic elements in the serum of micronutrient-deficient young women. A total of 40 women participated in this study and were divided into two groups: study group (n = 23) (with iron and folate deficiency) and control group (n = 17). The study group received iron and folic acid supplements for 3 months. Blood samples were collected at baseline and after the completion of the study period. Women completed a 3-day food intake record. We calculated the body mass index (BMI) of all the participants. Cellular morphology was analyzed in whole blood, and biochemical parameters were determined in serum. Elements were measured in serum by inductively coupled plasma mass spectrometry (ICP-MS). According to our results, in the case of the study group, the supplementation of iron and folic acid restored their levels; however, it caused a significant decrease in the level of zinc, calcium, and magnesium. In the case of the control group, at the end of the study period, there was a marked decrease in the level of iron. Interestingly, there was an increase in the level of arsenic and vanadium in both groups. In conclusion, simultaneous supplementation of iron and folic acid impairs the level of zinc, calcium, and magnesium in women of childbearing age.
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影响因子：
4.3
作者：
Bodiga, Sreedhar;Krishnapillai, Madhavan Nair
通讯作者：
Krishnapillai, Madhavan Nair
影响因子：
8.3
作者：
Ashrap, Pahriya;Watkins, Deborah J.;Meeker, John D.
通讯作者：
Meeker, John D.
影响因子：
6.3
作者：
Tiwari, Amit Kumar Mani;Mahdi, Abbas Ali;Negi, Mahendra Pal Singh
通讯作者：
Negi, Mahendra Pal Singh
DOI：
10.3961/jpmph.14.036
发表时间：
2014-09
期刊：
Journal of preventive medicine and public health = Yebang Uihakhoe chi
影响因子：
--
作者：
Chung JY;Yu SD;Hong YS
通讯作者：
Hong YS
影响因子：
5
作者：
Monica, Andrews;Lautaro, Briones;Miguel, Arredondo
通讯作者：
Miguel, Arredondo