Abnormal Functional Connectivity of Hippocampal Subdivisions in Obstructive Sleep Apnea: A Resting-State Functional Magnetic Resonance Imaging Study.
Abnormal Functional Connectivity of Hippocampal Subdivisions in Obstructive Sleep Apnea: A Resting-State Functional Magnetic Resonance Imaging Study.
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阻塞性睡眠呼吸暂停中海马分区的功能连接异常：静息态功能磁共振成像研究
DOI：
10.3389/fnins.2022.850940
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发表时间：
2022
影响因子：
4.3
通讯作者：
Peng, Dechang
中科院分区：
文献类型：
--
作者：
Liu, Xiang;Chen, Liting;Duan, Wenfeng;Li, Haijun;Kong, Linghong;Shu, Yongqiang;Li, Panmei;Li, Kunyao;Xie, Wei;Zeng, Yaping;Peng, Dechang
海马体参与各种认知功能，包括记忆。阻塞性睡眠呼吸暂停(OSA)患者已观察到海马区结构和功能的异常，但OSA患者海马区之间的功能连接(FC)模式尚不清楚。本研究旨在探讨男性阻塞性睡眠呼吸暂停综合征(OSA)患者海马区Fc的变化及其与神经认知功能的关系。对46例未经治疗的男性重度阻塞性睡眠呼吸暂停患者和46例睡眠良好的男性患者进行了静息状态fMRI检查。将大鼠海马区分为前、中、后三个亚区，并测定各亚区与其他脑区之间FC的差异。采用相关分析探讨阻塞性睡眠呼吸暂停综合征患者海马区Fc异常与临床特征的关系。结果显示，阻塞性睡眠呼吸暂停综合征组左侧前海马与左额中回之间、左侧中回与左额下回之间、右侧中央前回与左侧中央前回之间、左侧后海马与右侧额中回之间、右侧中回与左额下回之间以及右侧后海马与左额中回之间的FC增加。这些Fc异常主要表现在感觉运动网络、额顶叶网络和语义/默认模式网络，这些网络与OSA患者的神经认知功能障碍密切相关。这项研究加深了我们对阻塞性睡眠呼吸暂停综合征神经认知功能障碍的潜在病理生理机制的理解。
The hippocampus is involved in various cognitive function, including memory. Hippocampal structural and functional abnormalities have been observed in patients with obstructive sleep apnoea (OSA), but the functional connectivity (FC) patterns among hippocampal subdivisions in OSA patients remain unclear. The purpose of this study was to investigate the changes in FC between hippocampal subdivisions and their relationship with neurocognitive function in male patients with OSA. Resting-state fMRI were obtained from 46 male patients with untreated severe OSA and 46 male good sleepers. The hippocampus was divided into anterior, middle, and posterior parts, and the differences in FC between hippocampal subdivisions and other brain regions were determined. Correlation analysis was used to explore the relationships between abnormal FC of hippocampal subdivisions and clinical characteristics in patients with OSA. Our results revealed increased FC in the OSA group between the left anterior hippocampus and left middle temporal gyrus; between the left middle hippocampus and the left inferior frontal gyrus, right anterior central gyrus, and left anterior central gyrus; between the left posterior hippocampus and right middle frontal gyrus; between the right middle hippocampus and left inferior frontal gyrus; and between the right posterior hippocampus and left middle frontal gyrus. These FC abnormalities predominantly manifested in the sensorimotor network, fronto-parietal network, and semantic/default mode network, which are closely related to the neurocognitive impairment observed in OSA patients. This study advances our understanding of the potential pathophysiological mechanism of neurocognitive dysfunction in OSA.
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影响因子：
16.2
作者：
Fanselow, Michael S.;Dong, Hong-Wei
通讯作者：
Dong, Hong-Wei
影响因子：
9.6
作者：
Lal, Chitra;Strange, Charlie;Bachman, David
通讯作者：
Bachman, David
影响因子：
5.7
作者：
Nettekoven, Charlotte;Reck, Nicola;Lucas, Carolin Weiss
通讯作者：
Lucas, Carolin Weiss
DOI：
10.1016/j.tem.2016.02.003
发表时间：
2016-04
期刊：
Trends in endocrinology and metabolism: TEM
影响因子：
--
作者：
Mattis J;Sehgal A
通讯作者：
Sehgal A
影响因子：
3.1
作者：
Adnan, Areeba;Barnett, Alexander;McAndrews, Mary Pat
通讯作者：
McAndrews, Mary Pat