Ventromedial prefrontal neurons represent self-states shaped by vicarious fear in male mice.
Ventromedial prefrontal neurons represent self-states shaped by vicarious fear in male mice.
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DOI：
10.1038/s41467-023-39081-5
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发表时间：
2023-07-03
影响因子：
16.6
通讯作者：
Okuyama, Teruhiro
中科院分区：
文献类型：
--
作者：
Huang, Ziyan;Chung, Myung;Tao, Kentaro;Watarai, Akiyuki;Wang, Mu-Yun;Ito, Hiroh;Okuyama, Teruhiro
对他人在危险中引起的恐惧的感知会产生复杂的替代性恐惧反应和行为输出。在啮齿类动物中，观察同种动物接受厌恶刺激会导致逃跑和冻结行为。目前还不清楚这些行为自我状态在对他人恐惧的反应中是如何神经生理学表现的。在这里，我们评估这样的代表性的腹内侧前额叶皮层（vmPFC），一个重要的网站同情，在一个观察恐惧（OF）的范式在雄性小鼠。我们使用机器学习的方法对观察员小鼠在OF期间的刻板行为进行分类。vmPFC的光遗传抑制特异性地破坏了OF诱导的逃避行为。在体内钙离子成像显示，vmPFC神经群体代表其他和自我状态的混合信息。不同的亚群被其他人的恐惧反应激活和抑制，同时代表自我冻结状态。这种混合选择性需要来自前扣带皮层和基底外侧杏仁核的输入来调节OF诱导的逃避行为。啮齿类动物的观察性恐惧伴随着冻结和逃避行为。在这里，作者表明，腹内侧前额叶皮层（vmPFC）的抑制干扰逃避行为，具体地说，vmPFC神经活动代表了他者和自我状态的混合信息。
Perception of fear induced by others in danger elicits complex vicarious fear responses and behavioral outputs. In rodents, observing a conspecific receive aversive stimuli leads to escape and freezing behavior. It remains unclear how these behavioral self-states in response to others in fear are neurophysiologically represented. Here, we assess such representations in the ventromedial prefrontal cortex (vmPFC), an essential site for empathy, in an observational fear (OF) paradigm in male mice. We classify the observer mouse’s stereotypic behaviors during OF using a machine-learning approach. Optogenetic inhibition of the vmPFC specifically disrupts OF-induced escape behavior. In vivo Ca2+ imaging reveals that vmPFC neural populations represent intermingled information of other- and self-states. Distinct subpopulations are activated and suppressed by others’ fear responses, simultaneously representing self-freezing states. This mixed selectivity requires inputs from the anterior cingulate cortex and the basolateral amygdala to regulate OF-induced escape behavior. Observational fear is accompanied by both freezing and escape behavior in rodents. Here, the authors show that ventromedial prefrontal cortex (vmPFC) inhibition disrupts escape behavior specifically, and that vmPFC neural activity represents intermingled information of other- and self-states.
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影响因子：
25
作者：
Gangopadhyay P;Chawla M;Dal Monte O;Chang SWC
通讯作者：
Chang SWC
影响因子：
25
作者：
Burgos-Robles A;Kimchi EY;Izadmehr EM;Porzenheim MJ;Ramos-Guasp WA;Nieh EH;Felix-Ortiz AC;Namburi P;Leppla CA;Presbrey KN;Anandalingam KK;Pagan-Rivera PA;Anahtar M;Beyeler A;Tye KM
通讯作者：
Tye KM
影响因子：
3.4
作者：
Beadle JN;Paradiso S;Tranel D
通讯作者：
Tranel D
影响因子：
8.2
作者：
Eilam, D
通讯作者：
Eilam, D
影响因子：
5.3
作者：
Capuzzo, Giulia;Floresco, Stan B.
通讯作者：
Floresco, Stan B.