Direct, intraoperative observation of ~0.1 Hz hemodynamic oscillations in awake human cortex: implications for fMRI.
Direct, intraoperative observation of ~0.1 Hz hemodynamic oscillations in awake human cortex: implications for fMRI.
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DOI：
10.1016/j.neuroimage.2013.10.044
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发表时间：
2014-02-15
期刊：
影响因子：
5.7
通讯作者：
Hillman EM
中科院分区：
文献类型：
--
作者：
Rayshubskiy A;Wojtasiewicz TJ;Mikell CB;Bouchard MB;Timerman D;Youngerman BE;McGovern RA;Otten ML;Canoll P;McKhann GM 2nd;Hillman EM
在从小鼠到人类的各种物种中，已经多次观察到皮质血流动力学中几乎正弦的、大幅度的∼0.1HZ振荡。然而，在人类功能磁共振成像(FMRI)研究中，很少有人注意到或考虑到“慢正弦血流动力学振荡”(SSHO)的发生。因此，对SSHO的原因进行的调查很少，它们混淆功能磁共振分析的可能性，以及它们作为功能生物标记物的可能价值在很大程度上被忽视了。在这里，我们报告了直接观察到一名清醒的接受脑肿瘤手术的人的大脑皮质中的大幅度、正弦∼0.1HZ血流动力学振荡。术中多光谱光学本征信号成像(MS-OISI)显示SSHO在空间上定位于皮质的不同区域，呈波状传播，并涉及特定的软脑膜小动脉直径的振荡，证实这种影响不是全身血压波动的结果。从同一受试者手术前4天收集的功能磁共振数据显示，在同一区域周围可以检测到BOLD信号中的∼0.1HZ振荡。手术中的光学成像数据来自一名接受癫痫手术的患者，其中没有观察到正弦振荡，以供比较。利用术中成像和术前功能磁共振成像，对清醒的人脑中的0.1赫兹波进行的直接观察证实，SSHO存在于人脑中，并可以通过功能磁共振成像检测到。我们讨论了这种振荡的可能的生理基础及其与脑病理的潜在联系，强调了它与静息状态fMRI的相关性，以及它作为神经疾病功能诊断和描绘的新靶点的潜力。
An almost sinusoidal, large amplitude ∼0.1 Hz oscillation in cortical hemodynamics has been repeatedly observed in species ranging from mice to humans. However, the occurrence of ‘slow sinusoidal hemodynamic oscillations’ (SSHOs) in human functional magnetic resonance imaging (fMRI) studies is rarely noted or considered. As a result, little investigation into the cause of SSHOs has been undertaken, and their potential to confound fMRI analysis, as well as their possible value as a functional biomarker has been largely overlooked. Here, we report direct observation of large-amplitude, sinusoidal ∼0.1 Hz hemodynamic oscillations in the cortex of an awake human undergoing surgical resection of a brain tumor. Intraoperative multispectral optical intrinsic signal imaging (MS-OISI) revealed that SSHOs were spatially localized to distinct regions of the cortex, exhibited wave-like propagation, and involved oscillations in the diameter of specific pial arterioles, confirming that the effect was not the result of systemic blood pressure oscillations. fMRI data collected from the same subject 4 days prior to surgery demonstrates that ∼0.1 Hz oscillations in the BOLD signal can be detected around the same region. Intraoperative optical imaging data from a patient undergoing epilepsy surgery, in whom sinusoidal oscillations were not observed, is shown for comparison. This direct observation of the ‘0.1 Hz wave’ in the awake human brain, using both intraoperative imaging and pre-operative fMRI, confirms that SSHOs occur in the human brain, and can be detected by fMRI. We discuss the possible physiological basis of this oscillation and its potential link to brain pathologies, highlighting its relevance to resting-state fMRI and its potential as a novel target for functional diagnosis and delineation of neurological disease.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
2.9
作者：
Ances, Beau M.;Greenberg, Joel H.;Detre, John A.
通讯作者：
Detre, John A.
影响因子：
3.8
作者：
Bouchard MB;Chen BR;Burgess SA;Hillman EM
通讯作者：
Hillman EM
影响因子：
6.3
作者：
Hecht, Nils;Woitzik, Johannes;Vajkoczy, Peter
通讯作者：
Vajkoczy, Peter
影响因子：
6.2
作者：
Farin, A;Suzuki, SO;Canoll, P
通讯作者：
Canoll, P