Environmental Chemicals in an Urban Population of Pregnant Women and Their Newborns from San Francisco.
Environmental Chemicals in an Urban Population of Pregnant Women and Their Newborns from San Francisco.
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DOI：
10.1021/acs.est.6b03492
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发表时间：
2016-11-15
影响因子：
11.4
通讯作者：
Woodruff TJ
中科院分区：
文献类型：
--
作者：
Morello-Frosch R;Cushing LJ;Jesdale BM;Schwartz JM;Guo W;Guo T;Wang M;Harwani S;Petropoulou SE;Duong W;Park JS;Petreas M;Gajek R;Alvaran J;She J;Dobraca D;Das R;Woodruff TJ
在子宫内暴露于环境污染物可能会增加对健康产生不利影响的风险。我们测量了2010- 2011年期间在旧金山弗朗西斯科收集的77名产妇和65对脐带血样本中59种潜在有害化学物质的浓度，包括血清中的多氯联苯（PCB），有机氯农药（OCPs），多溴联苯醚（PBDEs），羟基化PBDEs（OH-PBDEs）和全氟化合物（PFCs）以及全血中的金属。与先前的研究一致，我们发现有证据表明，脐带血或血清中汞和低溴多溴二苯醚的浓度通常高于母体样本（脐带与母体比例中位数> 1），而对于大多数PFC和铅（Pb），脐带血或血清中的浓度通常等于或低于其母体样本（脐带与母体比例中位数≤ 1）。与最近一项审查的结论相反，我们发现有证据表明，当在调整脂质的基础上评估浓度时，脐带中的多氯联苯和有机氯农药含量往往高于母体血清（脐带与母体血清的中位数比值> 1）。我们的研究结果表明，对于许多化学品，胎儿可能比母亲经历更高的暴露，并强调需要描述潜在的健康风险，并为旨在减少暴露来源的政策提供信息。
Exposures to environmental pollutants in utero may increase the risk of adverse health effects. We measured the concentrations of 59 potentially harmful chemicals in 77 maternal and 65 paired umbilical cord blood samples collected in San Francisco during 2010-11, including polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), polybrominated diphenyl ethers (PBDEs), hydroxylated PBDEs (OH-PBDEs), and perfluorinated compounds (PFCs) in serum, and metals in whole blood. Consistent with previous studies, we found evidence that concentrations of mercury (Hg) and lower-brominated PBDEs were often higher in umbilical cord blood or serum than in maternal samples (median cord:maternal ratio > 1), while for most PFCs and lead (Pb), concentrations in cord blood or serum were generally equal to or lower than their maternal pair (median cord:maternal ratio ≤ 1). In contrast to the conclusions of a recent review, we found evidence that several PCBs and OCPs were also often higher in cord than maternal serum (median cord:maternal ratio > 1) when concentrations are assessed on a lipid-adjusted basis. Our findings suggest that for many chemicals, fetuses may experience higher exposures than their mothers, and highlight the need to characterize potential health risks and inform policies aimed at reducing sources of exposure.
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影响因子：
4.9
作者：
BARANOWSKA, I
通讯作者：
BARANOWSKA, I
影响因子：
10.4
作者：
Beesoon S;Webster GM;Shoeib M;Harner T;Benskin JP;Martin JW
通讯作者：
Martin JW
影响因子：
--
作者：
Crofton, Kevin M.
通讯作者：
Crofton, Kevin M.
影响因子：
9.8
作者：
Covaci, A;Jorens, P;Schepens, R
通讯作者：
Schepens, R
DOI：
10.1016/j.ijheh.2011.08.011
发表时间：
2012-02-01
影响因子：
6
作者：
Gutzkow, Kristine Bjerve;Haug, Line Smastuen;Brunborg, Gunnar
通讯作者：
Brunborg, Gunnar