C. elegans are protected from lethal hypoxia by an embryonic diapause.
C. elegans are protected from lethal hypoxia by an embryonic diapause.
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DOI：
10.1016/j.cub.2009.05.066
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发表时间：
2009-07-28
期刊：
影响因子：
--
通讯作者：
Roth MB
中科院分区：
文献类型：
--
作者：
Miller DL;Roth MB
至少有100种哺乳动物表现出胚胎滞育，受精胚胎在子宫内停止发育，直到遇到合适的季节或营养环境。推迟母体对生产后代的投资，使这些动物能够利用有限的资源生存，同时寻找更好的条件，并确保后代不产生时，他们不太可能生存。此外，胚胎在子宫内时可免受外部环境变迁的影响。在这里，我们展示了C。线虫，并表明这种滞育保护胚胎免受致命的缺氧。滞育胚胎在子宫内需要san-1才能存活，表明缺氧诱导的胚胎滞育可能与假死机制有关。此外，我们表明，神经元HIF-1活性在成人支配的O2张力在胚胎滞育是从事。我们认为，母亲对缺氧的感知通过诱导滞育（一种自然的假死形式）刺激了保护子宫内胚胎的反应。这种反应可能是一种重要的策略，以提高后代在恶劣条件下的生存，并允许成年人找到更适合繁殖成功的环境。
At least 100 mammalian species exhibit embryonic diapause, where fertilized embryos arrest development in utero until suitable seasonal or nutritional environments are encountered. Delaying maternal investments in producing offspring allows these animals to utilize limited resources to survive while searching for better conditions, and ensures that progeny are not produced when they are unlikely to survive. In addition, embryos may be protected from external environmental vicissitudes while in utero. Here we demonstrate embryonic diapause in C. elegans, and show that this diapause protects embryos from otherwise lethal hypoxia. Diapausing embryos in utero require san-1 to survive, indicating that hypoxia-induced embryonic diapause may be mechanistically related to suspended animation. Furthermore, we show that neuronal HIF-1 activity in the adult dictates the O2 tension at which embryonic diapause is engaged. We suggest that the maternal perception of hypoxia stimulates a response to protect embryos in utero by inducing diapause, a natural form of suspended animation. This response is likely to be an important strategy to improve offspring survival in harsh conditions and allow adults to find environments more suitable for reproductive success.
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影响因子：
9.8
作者：
Chang AJ;Chronis N;Karow DS;Marletta MA;Bargmann CI
通讯作者：
Bargmann CI
DOI：
10.1073/pnas.131213198
发表时间：
2001-06-19
影响因子：
11.1
作者：
Padilla, PA;Roth, MB
通讯作者：
Roth, MB
DOI：
10.1083/jcb.100.5.1623
发表时间：
1985-05
期刊：
The Journal of cell biology
影响因子：
--
作者：
Foe VE;Alberts BM
通讯作者：
Alberts BM
DOI：
10.1073/pnas.0403312101
发表时间：
2004-06-15
影响因子：
11.1
作者：
Nystul, TG;Roth, MB
通讯作者：
Roth, MB
影响因子：
4.6
作者：
Narbonne, P;Roy, R
通讯作者：
Roy, R