Developmental genetics of the 2E-F region of the Drosophila X chromosome: a region rich in "developmentally important" genes.

Developmental genetics of the 2E-F region of the Drosophila X chromosome: a region rich in "developmentally important" genes.
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果蝇 X 染色体 2E-F 区域的发育遗传学:该区域富含“发育重要”基因。

DOI:
10.1093/genetics/108.3.559
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发表时间:
1984
期刊:
影响因子:
3.3
通讯作者:
Mahowald,AP
Mahowald,AP
中科院分区:
生物学2区
文献类型:
--
作者:
Perrimon,N;Engstrom,L;Mahowald,AP

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我们分析了X染色体的2 E1 - 3A 1区域,特别注意与胚胎发生有关的位点。已发表的图谱表明,该染色体片段含有10条带。我们的遗传分析已经确定了11个互补组:一个隐性可见(修剪),两个雌性不育和八个致死。其中一个雌性不育位点是fs(1)k10,纯合雌性产生的卵室和胚胎都具有背侧形态。第二种雌性不育的是父亲可挽救的美洲山雀,其中未经挽救的胚胎具有肥大的神经系统。在这八个致死互补群中,有两个是隐性胚胎致死群:半合子巨(gt)胚胎具有节段缺陷,半合子曲颈(crn)胚胎表现出扭曲表型。对女性生殖细胞系中这些突变的分析表明,gt并没有表现出母体效应,而crn的正常活性是生殖细胞生存所必需的。在生殖系克隆的其余六个隐性致死互补组的母体效应的分析表明,四个是所需的生殖细胞的活力和一个生殖细胞的生存产生模棱两可的结果。剩下的,l(1)极孔,是一种隐性的早期蛹致死性,其中胚胎来自生殖系克隆和缺乏野生型基因活性表现出“躯干”或“极孔”表型。
We have analyzed the 2E1-3A1 area of theXchromosome with special attention to loci related to embryogenesis. Published maps indicate that this chromosomal segment contains ten bands. Our genetic analysis has identified 11 complementation groups: one recessive visible (prune), two female steriles and eight lethals. One of the female sterile loci isfs(1)k10for which homozygous females produce both egg chambers and embryos with a dorsalized morphology. The second female sterile is the paternally rescuablefs(1)pecanex in which unrescued embryos have a hypertrophic nervous system. Of the eight lethal complementation groups two are recessive embryonic lethals: hemizygous giant (gt) embryos possess segmental defects, and hemizygous crooked neck (crn) embryos exhibit a twisted phenotype. Analysis of these mutations in the female germ line indicates thatgtdoes not show a maternal effect, whereas normal activity ofcrnis required for germ cell viability. Analysis of the maternal effect in germ line clones of the remaining six recessive lethal complementation groups indicates that four are required for germ cell viability and one produces ambiguous results for survival of the germ cells. The remaining,l(1)pole hole, is a recessive early pupal lethal in which embryos derived from germ line clones and lacking wild-type gene activity exhibit the "torso" or "pole hole" phenotype.
母系影响胚胎致死率:果蝇雌性生育位点的等位基因特异性遗传拯救。
DOI: 10.1139/g76-092
发表时间: 1976
期刊: Canadian journal of genetics and cytology. Journal canadien de genetique et de cytologie
影响因子: --
作者:
P. Romans;R. Hodgetts;D. Nash
通讯作者: D. Nash
结合遗传和镶嵌方法研究果蝇卵子发生。
DOI: 10.1007/978-1-4684-7968-3_7
发表时间: 1980
期刊: Basic life sciences
影响因子: --
作者:
E. Wieschaus
通讯作者: E. Wieschaus
DOI: 10.1016/0012-1606(83)90231-2
发表时间: 1983-01-01
影响因子: 2.7
作者:
PERRIMON, N;GANS, M
通讯作者: GANS, M
合子致死突变对果蝇雌性种系功能的影响。
DOI: 10.1016/0012-1606(84)90297-5
发表时间: 1984
影响因子: 2.7
作者:
Perrimon,N;Engstrom,L;Mahowald,AP
通讯作者: Mahowald,AP
DOI: --
发表时间: 1977
期刊: Genetics
影响因子: 3.3
作者:
J. Mohler
通讯作者: J. Mohler