The effects of serotonin modulation on medial prefrontal connectivity strength and stability: A pharmacological fMRI study with citalopram.
The effects of serotonin modulation on medial prefrontal connectivity strength and stability: A pharmacological fMRI study with citalopram.
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DOI：
10.1016/j.pnpbp.2018.01.021
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发表时间：
2018-06-08
影响因子：
5.6
通讯作者：
Selvaraj S
中科院分区：
文献类型：
--
作者：
Arnone D;Wise T;Walker C;Cowen PJ;Howes O;Selvaraj S
静态和动态功能连接越来越多地被用来衡量疾病和一系列不同干预措施对大脑网络的影响。虽然初步证据表明，在健康人和重度抑郁症患者中，长期服用抗抑郁药可以调节静态连接，但对抗抑郁药的急性影响，特别是对动态功能连接变化的影响，我们知之甚少。在这里，我们研究了抗抑郁药物对默认模式网络中动态功能连接的急性影响。默认模式网络是一个描述良好的网络，具有许多功能，其中5-羟色胺的作用尚不清楚。在这项工作中，我们测量了选择性5-羟色胺再摄取抑制剂(SSRI)西酞普兰10 mg输注的急性药理学效应，13名健康志愿者随机接受两次交叉剂量的活性化合物或安慰剂。与安慰剂相比，急性给予西酞普兰可增加内侧前额叶皮质与右侧背外侧前额叶皮质和后扣带回皮质之间的静态连接。SSRI还导致在楔前和后扣带皮质与内侧前额叶皮质连接的变异性降低。测量的变化与修改后的5-羟色胺皮质可利用度是一致的。
Static and dynamic functional connectivity are being increasingly used to measure the effects of disease and a range of different interventions on brain networks. Whilst preliminary evidence suggests that static connectivity can be modulated by chronic antidepressants administration in healthy individuals and in major depression, much less is known about the acute effects of antidepressants especially on dynamic functional connectivity changes. Here we examine acute effects of antidepressants on dynamic functional connectivity within the default mode network. The default mode network is a well described network with many functions in which the role of serotonin is not clear. In this work we measured acute pharmacological effects of an infusion of the selective serotonin reuptake inhibitor (SSRI) citalopram 10 mg in a sample of thirteen healthy volunteers randomised to receive on two occasions the active compound or placebo in a cross over dosing. Acute citalopram administration relative to placebo increased static connectivity between the medial prefrontal cortex and right dorsolateral prefrontal cortex and posterior cingulate cortex. The SSRI also induced a reduction in variability of connectivity with the medial prefrontal cortex in the precuneus and posterior cingulate cortex. The measured changes are compatible with modified serotonin cortical availability.
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