Associations among oxytocin receptor gene (OXTR) DNA methylation in adulthood, exposure to early life adversity, and childhood trajectories of anxiousness.
Associations among oxytocin receptor gene (OXTR) DNA methylation in adulthood, exposure to early life adversity, and childhood trajectories of anxiousness.
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DOI：
10.1038/s41598-017-07950-x
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发表时间：
2017-08-07
影响因子：
4.6
通讯作者：
Vitaro F
中科院分区：
文献类型：
--
作者：
Gouin JP;Zhou QQ;Booij L;Boivin M;Côté SM;Hébert M;Ouellet-Morin I;Szyf M;Tremblay RE;Turecki G;Vitaro F
最近的模型提出关键神经调节基因的脱氧核糖核酸甲基化是与早期生活逆境（ELA）相关的精神障碍风险增加的分子机制。本研究的目的是研究ELA与年轻人催产素受体基因（OXTR）甲基化的关系。从一个21年的纵向队列中，我们比较了46名成年人（23名男性和23名女性）的成年OXTR甲基化频率，这些成年人根据儿童期的社会经济地位和儿童期和青少年期的身体和性虐待暴露而选择高或低ELA暴露。还评估了OXTR甲基化与教师评定的童年焦虑轨迹之间的关联。在女性中，ELA暴露与第一个内含子中的一个重要CpG位点相关，但在男性中则不然。同样，童年焦虑的轨迹与女性启动子区域内的一个重要CpG位点有关，但在男性中则不然。这项研究表明，女性可能比男性对ELA对OXTR甲基化的影响更敏感。
Recent models propose deoxyribonucleic acid methylation of key neuro-regulatory genes as a molecular mechanism underlying the increased risk of mental disorder associated with early life adversity (ELA). The goal of this study was to examine the association of ELA with oxytocin receptor gene (OXTR) methylation among young adults. Drawing from a 21-year longitudinal cohort, we compared adulthood OXTR methylation frequency of 46 adults (23 males and 23 females) selected for high or low ELA exposure based on childhood socioeconomic status and exposure to physical and sexual abuse during childhood and adolescence. Associations between OXTR methylation and teacher-rated childhood trajectories of anxiousness were also assessed. ELA exposure was associated with one significant CpG site in the first intron among females, but not among males. Similarly, childhood trajectories of anxiousness were related to one significant CpG site within the promoter region among females, but not among males. This study suggests that females might be more sensitive to the impact of ELA on OXTR methylation than males.
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影响因子：
3.7
作者：
Chagnon YC;Potvin O;Hudon C;Préville M
通讯作者：
Préville M
影响因子：
3.3
作者：
Bick J;Naumova O;Hunter S;Barbot B;Lee M;Luthar SS;Raefski A;Grigorenko EL
通讯作者：
Grigorenko EL
影响因子：
11
作者：
Cecil, C. A. M.;Lysenko, L. J.;Jaffee, S. R.;Pingault, J-B;Smith, R. G.;Relton, C. L.;Woodward, G.;McArdle, W.;Mill, J.;Barker, E. D.
通讯作者：
Barker, E. D.
影响因子：
10.6
作者：
Champagne, Frances A.;Meaney, Michael J.
通讯作者：
Meaney, Michael J.
影响因子：
3
作者：
Curley, James P.;Davidson, Stephanie;Champagne, Frances A.
通讯作者：
Champagne, Frances A.