From Raman to SESORRS: moving deeper into cancer detection and treatment monitoring.
From Raman to SESORRS: moving deeper into cancer detection and treatment monitoring.
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从拉曼到感应器：深入癌症检测和治疗监测。
DOI：
10.1039/d1cc04805h
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发表时间：
2021-11-23
期刊：
影响因子：
--
通讯作者：
Faulds K
中科院分区：
文献类型：
--
作者：
Sloan-Dennison S;Laing S;Graham D;Faulds K
拉曼光谱是一种非侵入性技术，可以从各种类型的样品中获得特定的化学信息。存在于拉曼光谱中的详细分子信息允许监测在疾病（例如癌症）中发生的生物化学变化，并且可以用于疾病的早期检测和诊断、用于监测治疗以及区分癌性和非癌性生物样品。已经开发了几种技术来通过提高检测灵敏度、减少成像时间和增加体内分析的潜在适用性来增强拉曼光谱的能力。不同的拉曼技术各自具有其自身的优点，可以适应替代的检测形式，从而允许这些技术以多种方式应用于癌症的检测和诊断。这篇专题文章讨论了各种形式的拉曼光谱，它们如何被应用于癌症检测，以及这些技术在体内癌症检测和临床诊断中的应用。尽管拉曼光谱学取得了进展，但该技术的临床应用仍然有限，必须克服某些挑战才能实现临床转化。我们提供了一个展望未来的技术在这一领域，我们认为是必要的，让潜在的拉曼光谱，以实现临床癌症诊断。本文讨论了各种拉曼光谱技术的使用，以及它们如何应用于癌症诊断和监测癌症治疗的不同检测方法，并展望了它们如何进入临床环境。
Raman spectroscopy is a non-invasive technique that allows specific chemical information to be obtained from various types of sample. The detailed molecular information that is present in Raman spectra permits monitoring of biochemical changes that occur in diseases, such as cancer, and can be used for the early detection and diagnosis of the disease, for monitoring treatment, and to distinguish between cancerous and non-cancerous biological samples. Several techniques have been developed to enhance the capabilities of Raman spectroscopy by improving detection sensitivity, reducing imaging times and increasing the potential applicability for in vivo analysis. The different Raman techniques each have their own advantages that can accommodate the alternative detection formats, allowing the techniques to be applied in several ways for the detection and diagnosis of cancer. This feature article discusses the various forms of Raman spectroscopy, how they have been applied for cancer detection, and the adaptation of the techniques towards their use for in vivo cancer detection and in clinical diagnostics. Despite the advances in Raman spectroscopy, the clinical application of the technique is still limited and certain challenges must be overcome to enable clinical translation. We provide an outlook on the future of the techniques in this area and what we believe is required to allow the potential of Raman spectroscopy to be achieved for clinical cancer diagnostics. This article discusses the use of various Raman spectroscopy techniques and how they have been applied to different methods of detection for the diagnosis of cancer and in monitoring cancer treatment, with an outlook on how they can progress into a clinical environment.
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