Prevalence of allergic sensitization in the United States: results from the National Health and Nutrition Examination Survey (NHANES) 2005-2006.
Prevalence of allergic sensitization in the United States: results from the National Health and Nutrition Examination Survey (NHANES) 2005-2006.
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DOI：
10.1016/j.jaci.2013.12.1071
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发表时间：
2014-08
影响因子：
14.2
通讯作者：
Zeldin, Darryl C.
中科院分区：
文献类型：
--
作者：
Salo, Paeivi M.;Arbes, Samuel J., Jr.;Jaramillo, Renee;Calatroni, Agustin;Weir, Charles H.;Sever, Michelle L.;Hoppin, Jane A.;Rose, Kathryn M.;Liu, Andrew H.;Gergen, Peter J.;Mitchell, Herman E.;Zeldin, Darryl C.
过敏性致敏是特应性疾病发展的重要危险因素。2005-2006年国家健康和营养检查调查（NHANES）提供了美国普通人群中IgE介导致敏的最全面信息。我们调查了过敏性致敏的聚集性、社会人口统计学和区域模式，并检查了与IgE介导的致敏相关的风险因素。该横断面分析的数据来自2005-2006年的NHANES。对年龄≥1岁的受试者（N=9440）进行吸入性和食物过敏原sIgE检测;对年龄≥6岁的受试者进行19次sIgE检测，对1-5岁的儿童进行9次sIgE检测。使用ImmunoCAP系统分析血清样品。通过问卷调查收集有关人口统计学和参与者特征的信息。在6岁及以上的研究人群中，44.6%的人可检测到sIgE，而36.2%的1-5岁儿童对≥1种过敏原致敏。过敏原特异性IgE分为7组，可能在很大程度上反映了生物学交叉反应性。尽管对个别过敏原和过敏原类型的致敏表现出区域差异，但除幼儿期外，各普查地区的致敏总体患病率没有差异。在多变量建模中，年轻、男性、非西班牙裔黑人种族/民族、地理位置（人口普查地区）和报告的宠物回避措施与IgE介导的致敏性最相关。过敏性致敏的总体患病率在美国人口普查地区之间没有变化，除了在早期生活中，尽管过敏原特异性致敏因社会人口统计学和地区因素而异。生物交叉反应性可能是过敏原特异性IgE聚集的重要因素，但不是唯一因素。IgE介导的致敏显示出聚集模式，并因社会人口和区域因素而异，但致敏的总体患病率在美国人口普查地区可能没有变化。
Allergic sensitization is an important risk factor for the development of atopic disease. The National Health and Nutrition Examination Survey (NHANES) 2005–2006 provides the most comprehensive information on IgE-mediated sensitization in the general US population. We investigated clustering, sociodemographic and regional patterns of allergic sensitization and examined risk factors associated with IgE-mediated sensitization. Data for this cross-sectional analysis were obtained from NHANES 2005–2006. Participants aged ≥1 year (N=9440) were tested for sIgEs to inhalant and food allergens; participants ≥6 years were tested for 19 sIgEs, and children aged 1–5 years for 9 sIgEs. Serum samples were analyzed using the ImmunoCAP System. Information on demographics and participant characteristics was collected by questionnaire. Of the study population aged 6 and older, 44.6% had detectable sIgEs, while 36.2% of children aged 1–5 years were sensitized to ≥1 allergen. Allergen-specific IgEs clustered into 7 groups that might have largely reflected biological cross-reactivity. Although sensitization to individual allergens and allergen types showed regional variation, the overall prevalence of sensitization did not differ across census regions, except in early childhood. In multivariate modeling, young age, male gender, non-Hispanic black race/ethnicity, geographic location (census region), and reported pet avoidance measures were most consistently associated with IgE-mediated sensitization. The overall prevalence of allergic sensitization does not vary across US census regions, except in early life, although allergen-specific sensitization differs by sociodemographic and regional factors. Biological cross-reactivity may be an important, but not a sole, contributor to the clustering of allergen-specific IgEs. IgE-mediated sensitization shows clustering patterns and differs by sociodemographic and regional factors, but the overall prevalence of sensitization may not vary across US census regions.
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影响因子：
3.7
作者：
Lødrup Carlsen KC;Roll S;Carlsen KH;Mowinckel P;Wijga AH;Brunekreef B;Torrent M;Roberts G;Arshad SH;Kull I;Krämer U;von Berg A;Eller E;Høst A;Kuehni C;Spycher B;Sunyer J;Chen CM;Reich A;Asarnoj A;Puig C;Herbarth O;Mahachie John JM;Van Steen K;Willich SN;Wahn U;Lau S;Keil T;GALEN WP 1.5 ‘Birth Cohorts’ working group
通讯作者：
GALEN WP 1.5 ‘Birth Cohorts’ working group
影响因子：
2.6
作者：
Bufford, JD;Gem, JE
通讯作者：
Gem, JE
影响因子：
6.9
作者：
Havstad, Suzanne L.;Johnson, Christine Cole;Wegienka, Ganesa
通讯作者：
Wegienka, Ganesa
影响因子：
14.2
作者：
GERGEN, PJ;TURKELTAUB, PC
通讯作者：
TURKELTAUB, PC
影响因子：
5.6
作者：
Bousquet, Philippe-Jean;Castelli, Christel;Burney, Peter
通讯作者：
Burney, Peter