Mother's age at menarche and offspring size.
Mother's age at menarche and offspring size.
复制标题
DOI：
10.1038/ijo.2010.104
复制
发表时间：
2010-12
影响因子：
4.9
通讯作者：
Longnecker, M. P.
中科院分区：
文献类型：
--
作者：
Basso, O.;Pennell, M. L.;Chen, A.;Longnecker, M. P.
一个人的成长轨迹，至少部分是遗传的。母亲初潮年龄较早与后代身高较高和9岁时体重指数（BMI）较高有关，这表明母亲初潮年龄可能是生长的代际标志。我们在围产期合作项目（CPP）中研究了母亲初潮年龄与出生时以及1岁、3岁、4岁、7岁和8岁儿童体型之间的关系。我们检查了31,474名黑人和白色儿童的128,636个测量值。我们将原始测量值转换为z分数。在混合模型中检查儿童尺寸，调整中心，儿童性别，种族，社会经济指数，儿童测量时的确切年龄（月），母亲招募时的年龄，以及母亲的身高，孕前体重或BMI（取决于特定模型中的结果）。与母亲在15岁或15岁以后月经初潮的儿童相比，母亲在12岁之前月经初潮的儿童从1岁起身高较高，7岁和8岁时的BMI较高（分别为0.17和0.19 z）。母亲初潮的年龄是孩子成长轨迹的适度预测因素。这种机制可能是遗传的，尽管其他解释也是可能的。
An individual’s growth trajectory is, at least in part, inherited. Mother’s early age at menarche has been associated with taller offspring height and greater body mass index (BMI) at age 9 years, suggesting that mother’s age at menarche may be an intergenerational marker of growth. We examined the association between mother’s age at menarche and childhood size at birth, and at the ages 1, 3, 4, 7, and 8 years in the Collaborative Perinatal Project (CPP). We examined 128,636 measurements from 31,474 Black and White children. We transformed the original measurements into z-scores. Child size was examined in mixed models, adjusted for center, child sex, race, socioeconomic index, child’s exact age at measurement (in months), mother's age at recruitment and, depending on which measure was the outcome in the specific model, mother's height, pre-pregnancy weight, or BMI. Compared with children whose mother had menarche at age 15 or later, children whose mothers had age at menarche before age 12 were taller from age 1 and had higher BMI at ages 7 and 8 (0.17 and 0.19 z, respecively). Mother’s age at menarche is a modest predictor of their children’s growth trajectory. The mechanism is likely to be heritable, although other explanations are possible.
登录
查看更多内容
影响因子：
15.8
作者：
Ong KK;Northstone K;Wells JC;Rubin C;Ness AR;Golding J;Dunger DB
通讯作者：
Dunger DB
影响因子：
8
作者：
Anderson, SE;Dallal, GE;Must, A
通讯作者：
Must, A
影响因子：
8.9
作者：
Monteiro, POA;Victora, CG
通讯作者：
Victora, CG
影响因子：
7.1
作者：
GUO, SS;ROCHE, AF;SIERVOGEL, RM
通讯作者：
SIERVOGEL, RM
影响因子：
7.7
作者：
Chen, AM;Pennell, ML;Longnecker, MP
通讯作者：
Longnecker, MP