Glycosylation Changes in Brain Cancer.
Glycosylation Changes in Brain Cancer.
复制标题
脑癌中的糖基化变化。
DOI：
10.1021/acschemneuro.7b00271
复制
发表时间：
2018-01-17
影响因子：
5
通讯作者：
Mechref Y
中科院分区：
文献类型：
--
作者：
Veillon L;Fakih C;Abou-El-Hassan H;Kobeissy F;Mechref Y
蛋白质糖基化是一种翻译后修饰，影响超过一半的已知蛋白质。与生物分子共价结合的聚糖通过直接相互作用（如结合伴侣识别聚糖结构）和间接机制（有助于控制蛋白质构象、稳定性和转换）调节其功能。本文重点对与脑癌相关的异常糖基化进行了综述。N-和O-聚糖的唾液酸化和岩藻糖基化改变在脑癌的发生和进展中起作用。此外，异常的0-聚糖表达与脑癌有关。本文还讨论了异常糖基化检测和治疗脑癌的临床潜力和应用。聚糖在脑癌治疗方法的发展中可能发挥的作用以及癌症糖蛋白组学和个性化医疗都得到了解决。糖蛋白改变被认为是癌症的标志，而体液中的高表达则代表了癌症评估的机会。
Protein glycosylation is a posttranslational modification that affects more than half of all known proteins. Glycans covalently bound to biomolecules modulate their functions by both direct interactions, such as the recognition of glycan structures by binding partners, and indirect mechanisms that contribute to the control of protein conformation, stability, and turnover. The focus of this review is the discussion of aberrant glycosylation related to brain cancer. Altered sialylation and fucosylation of N- and O-glycans play a role in the development and progression of brain cancer. Additionally, aberrant O-glycan expression has been implicated in brain cancer. This review also addresses the clinical potential and applications of aberrant glycosylation for the detection and treatment of brain cancer. The viable roles glycans may play in the development of brain cancer therapeutics are addressed as well as cancer-glycoproteomics and personalized medicine. Glycoprotein alterations are considered as a hallmark of cancer while high expression in body fluids represents an opportunity for cancer assessment.
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影响因子：
--
作者：
Cascio S;Farkas AM;Hughey RP;Finn OJ
通讯作者：
Finn OJ
影响因子：
28.2
作者：
Arnal-Estapé A;Nguyen DX
通讯作者：
Nguyen DX
DOI：
10.1016/j.bbrc.2005.07.037
发表时间：
2005-09-16
影响因子：
3.1
作者：
Camby, I;Decaestecker, C;Kiss, R
通讯作者：
Kiss, R
影响因子：
3.2
作者：
Cao, Y;Blohm, D;Karsten, U
通讯作者：
Karsten, U
影响因子：
2.9
作者：
Chen, Guoqiang;Wang, Yanmin;Li, Zhili
通讯作者：
Li, Zhili