Origins of specificity during tDCS: anatomical, activity-selective, and input-bias mechanisms.
Origins of specificity during tDCS: anatomical, activity-selective, and input-bias mechanisms.
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DOI：
10.3389/fnhum.2013.00688
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发表时间：
2013
影响因子：
2.9
通讯作者：
Rahman A
中科院分区：
文献类型：
--
作者：
Bikson M;Name A;Rahman A
经颅直流电刺激（tDCS）被研究用于广泛的神经精神适应症，各种康复应用，以及调节各种任务中的认知表现。tDCS的特异性广泛地指的是tDCS产生精确的，而不是弥漫性的脑功能变化的能力。实际上，tDCS的特异性意味着协议的特定应用定制，以最大限度地提高预期结果并最大限度地减少不期望的影响。特别是考虑到tDCS的简单性和大脑功能的复杂性，理解导致特异性的机制是tDCS合理发展的基础。我们根据解剖学和功能因素定义特异性的起源。解剖特异性来自于引导电流到目标脑结构。功能特异性可以来自于活动选择性，其中活动神经元网络优先由tDCS调制，或输入选择性，其中偏置被施加到不同的突触输入。tDCS的合理推进可能需要利用所有形式的特异性。
Transcranial Direct Current Stimulation (tDCS) is investigated for a broad range of neuropsychiatric indications, various rehabilitation applications, and to modulate cognitive performance in diverse tasks. Specificity of tDCS refers broadly to the ability of tDCS to produce precise, as opposed to diffuse, changes in brain function. Practically, specificity of tDCS implies application-specific customization of protocols to maximize desired outcomes and minimize undesired effects. Especially given the simplicity of tDCS and the complexity of brain function, understanding the mechanisms leading to specificity is fundamental to the rational advancement of tDCS. We define the origins of specificity based on anatomical and functional factors. Anatomical specificity derives from guiding current to targeted brain structures. Functional specificity may derive from either activity-selectivity, where active neuronal networks are preferentially modulated by tDCS, or input-selectivity, where bias is applied to different synaptic inputs. Rational advancement of tDCS may require leveraging all forms of specificity.
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影响因子：
7.7
作者：
Brunoni, Andre Russowsky;Nitsche, Michael A.;Bolognini, Nadia;Bikson, Marom;Wagner, Tim;Merabet, Lotfi;Edwards, Dylan J.;Valero-Cabre, Antoni;Rotenberg, Alexander;Pascual-Leone, Alvaro;Ferrucci, Roberta;Priori, Alberto;Boggio, Paulo Sergio;Fregni, Felipe
通讯作者：
Fregni, Felipe
DOI：
10.1523/jneurosci.4927-12.2013
发表时间：
2013-03-06
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Iuculano T;Cohen Kadosh R
通讯作者：
Cohen Kadosh R
影响因子：
64.8
作者：
BINDMAN, LJ;LIPPOLD, OCJ;REDFEARN, JW
通讯作者：
REDFEARN, JW
DOI：
10.1109/embc.2012.6347465
发表时间：
2012
期刊：
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
影响因子：
--
作者：
Dmochowski JP;Bikson M;Datta A;Richardson J;Fridriksson J;Parra LC
通讯作者：
Parra LC
影响因子：
4.7
作者：
Dieckhoefer, Anne;Waberski, Till Dino;Gobbele, Rene
通讯作者：
Gobbele, Rene