Oxytocin's inhibitory effect on food intake is stronger in obese than normal-weight men.
Oxytocin's inhibitory effect on food intake is stronger in obese than normal-weight men.
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DOI：
10.1038/ijo.2016.149
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发表时间：
2016-11
影响因子：
4.9
通讯作者：
Hallschmid, M.
中科院分区：
文献类型：
--
作者：
Thienel, M.;Fritsche, A.;Heinrichs, M.;Peter, A.;Ewers, M.;Lehnert, H.;Born, J.;Hallschmid, M.
动物研究和对男性的初步实验表明，下丘脑神经肽催产素限制了食物的摄入量，并提出了它是否有可能改善肥胖患者的代谢控制的问题。我们比较了18名年轻肥胖男性和20名正常体重男性经鼻腔注射中枢神经催产素(24 IU)对摄食行为和代谢功能的影响。在双盲、安慰剂对照试验中，受试者在给予催产素45 分钟后，从测试自助餐中随机摄取食物，然后评估餐后奖励驱动的零食摄入量。用间接量热法重复评估能量消耗，并采血测定血糖和激素浓度。催产素显著减少了肥胖男性禁食状态下饥饿驱动的食物摄入量，但对正常体重的男性没有影响，并导致两组人零食消费量的减少，而能量消耗总体上没有受到影响。两组下丘脑-垂体-肾上腺轴分泌和餐后血糖升高均被催产素抑制。催产素对食物摄入量产生强烈的抑制作用，与正常体重的男性相比，肥胖男性的这种影响是增强的，而不是减少的。这种模式使其与其他代谢活性神经肽形成对比，并预示着催产素在治疗代谢紊乱方面的临床应用前景良好。
Animal studies and pilot experiments in men indicate that the hypothalamic neuropeptide oxytocin limits food intake, and raise the question of its potential to improve metabolic control in obesity. We compared the effect of central nervous oxytocin administration (24 IU) via the intranasal route on ingestive behaviour and metabolic function in 18 young obese men with the results in a group of 20 normal-weight men. In double-blind, placebo-controlled experiments, ad libitum food intake from a test buffet was examined in fasted subjects 45 min after oxytocin administration, followed by the assessment of postprandial, reward-driven snack intake. Energy expenditure was repeatedly assessed by indirect calorimetry and blood was sampled to determine concentrations of blood glucose and hormones. Oxytocin markedly reduced hunger-driven food intake in the fasted state in obese but not in normal-weight men, and led to a reduction in snack consumption in both groups, whereas energy expenditure remained generally unaffected. Hypothalamic–pituitary–adrenal axis secretion and the postprandial rise in plasma glucose were blunted by oxytocin in both groups. Oxytocin exerts an acutely inhibitory impact on food intake that is enhanced rather than decreased in obese compared with normal-weight men. This pattern puts it in contrast to other metabolically active neuropeptides and bodes well for clinical applications of oxytocin in the treatment of metabolic disorders.
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DOI：
10.1152/ajpregu.00604.2003
发表时间：
2004-07-01
影响因子：
2.8
作者：
Blevins, JE;Schwartz, MW;Baskin, DG
通讯作者：
Baskin, DG
影响因子：
7.7
作者：
Hallschmid M;Higgs S;Thienel M;Ott V;Lehnert H
通讯作者：
Lehnert H
影响因子：
5.2
作者：
Maejima, Yuko;Iwasaki, Yusaku;Yada, Toshihiko
通讯作者：
Yada, Toshihiko
影响因子：
3
作者：
ARLETTI, R;BENELLI, A;BERTOLINI, A
通讯作者：
BERTOLINI, A
影响因子：
25
作者：
Diekelmann, Susanne;Buechel, Christian;Rasch, Bjoern
通讯作者：
Rasch, Bjoern