The oral microbiome, pancreatic cancer and human diversity in the age of precision medicine.
The oral microbiome, pancreatic cancer and human diversity in the age of precision medicine.
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DOI：
10.1186/s40168-022-01262-7
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发表时间：
2022-06-15
期刊：
影响因子：
15.5
通讯作者：
Trevino, Jose G.
中科院分区：
文献类型：
--
作者：
Herremans, Kelly M.;Riner, Andrea N.;Cameron, Miles E.;McKinley, Kelley L.;Triplett, Eric W.;Hughes, Steven J.;Trevino, Jose G.
胰腺癌是一种致命的疾病，诊断和治疗选择有限。由于胰腺癌的患病率、治疗和结果存在差异，并非所有人群都受到同样的影响。最近，下一代测序促进了对人类口腔微生物组的更全面分析，为其在精准医学中的应用创造了机会。口腔微生物转移发生在胰腺癌患者中，这可能在诊断前几年就被发现了。此外，在胰腺肿瘤中也发现了口腔中常见的致病菌。尽管有这些发现，对于胰腺癌患者的口腔微生物组如何或为什么不同，仍有很多未知之处。随着个体的发展，他们的口腔微生物组反映了他们的基因型和环境影响。遗传、种族/民族、吸烟、社会经济和年龄影响口腔微生物群的组成，这可能最终在胰腺癌的发生中起作用。多种机制被提出来解释在胰腺癌患者中发现的口腔生态失调，尽管它们尚未得到证实。随着对口腔微生物组与胰腺癌之间相互作用的更好理解，可以实施改进的诊断和治疗方法，以减少医疗保健差距。视频摘要本文的补充信息在10.1186/s40168-022-01262-7。
Pancreatic cancer is a deadly disease with limited diagnostic and treatment options. Not all populations are affected equally, as disparities exist in pancreatic cancer prevalence, treatment and outcomes. Recently, next-generation sequencing has facilitated a more comprehensive analysis of the human oral microbiome creating opportunity for its application in precision medicine. Oral microbial shifts occur in patients with pancreatic cancer, which may be appreciated years prior to their diagnosis. In addition, pathogenic bacteria common in the oral cavity have been found within pancreatic tumors. Despite these findings, much remains unknown about how or why the oral microbiome differs in patients with pancreatic cancer. As individuals develop, their oral microbiome reflects both their genotype and environmental influences. Genetics, race/ethnicity, smoking, socioeconomics and age affect the composition of the oral microbiota, which may ultimately play a role in pancreatic carcinogenesis. Multiple mechanisms have been proposed to explain the oral dysbiosis found in patients with pancreatic cancer though they have yet to be confirmed. With a better understanding of the interplay between the oral microbiome and pancreatic cancer, improved diagnostic and therapeutic approaches may be implemented to reduce healthcare disparities. Video Abstract Supplementary information accompanies this paper at 10.1186/s40168-022-01262-7.
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