Preeclampsia, antihypertensive medication use in pregnancy and risk of childhood cancer in offspring.
Preeclampsia, antihypertensive medication use in pregnancy and risk of childhood cancer in offspring.
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DOI：
10.1007/s10552-023-01745-4
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发表时间：
2024-01
影响因子：
2.3
通讯作者：
Heck, Julia E.
中科院分区：
文献类型：
--
作者：
Askins, Lexie;Orimoloye, Helen T.;Deng, Chuanjie;Hansen, Johnni;Olsen, Jorn;Ritz, Beate;Janzen, Carla;Heck, Julia E.
Preeclampsia is a serious pregnancy complication that presents a significant risk to both the mother and the fetus. Preeclampsia and medications associated with its treatment are potentially linked to increased childhood cancer risk. Therefore, we examined the association between preeclampsia, antihypertensive medications, and childhood cancer in offspring. Cases (n = 6,420) and controls (n = 160,484) were obtained from Danish national registries. We performed conditional logistic regression analyses to estimate the association between preeclampsia and childhood cancer risk, and examined the effects of antihypertensive medication use in pregnancy in relation to childhood cancer risk in the offspring with adjustment for relevant covariates. We observed an increased risk of acute lymphoblastic leukemia (ALL) among those whose mothers had preeclampsia (OR = 1.36, 95% CI 1.03, 1.79), especially for severe preeclampsia (OR = 2.36, 95% CI 1.37, 4.08). We also estimated an increased cancer risk in children born to mothers who were prescribed diuretics during pregnancy [OR = 2.09, 95% confidence interval (CI) 1.39, 3.14]. Intake of other antihypertensive medications was not associated with childhood cancer (OR = 0.78, 95% CI 0.50, 1.23). Among women who did not take diuretics in pregnancy, preeclampsia was associated with neuroblastoma (OR = 2.22, 95% CI 1.08, 4.55). Our findings suggested an increased risk for certain types of cancer in the offspring of mothers with preeclampsia and an increased risk of cancer with diuretic intake during pregnancy. The online version contains supplementary material available at 10.1007/s10552-023-01745-4.
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影响因子：
3.2
作者：
Heck, Julia E.;He, Di;Hansen, Johnni
通讯作者：
Hansen, Johnni
影响因子：
7.2
作者：
Hauth, JC;Ewell, MG;Morris, CD
通讯作者：
Morris, CD
影响因子：
5
作者：
Cook, MN;Olshan, AF;Pollock, BH
通讯作者：
Pollock, BH
影响因子：
2.6
作者：
Heck, Julia E.;Meyers, Travis J.;Lombardi, Christina;Park, Andrew S.;Cockburn, Myles;Reynolds, Peggy;Ritz, Beate
通讯作者：
Ritz, Beate
影响因子：
8.8
作者：
HARTLEY, AL;BIRCH, JM;WATERHOUSE, JAH
通讯作者：
WATERHOUSE, JAH