A meta-analysis of functional neuroimaging studies of self- and other judgments reveals a spatial gradient for mentalizing in medial prefrontal cortex.
A meta-analysis of functional neuroimaging studies of self- and other judgments reveals a spatial gradient for mentalizing in medial prefrontal cortex.
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DOI：
10.1162/jocn_a_00233
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发表时间：
2012-08
影响因子：
3.2
通讯作者：
Ochsner KN
中科院分区：
文献类型：
--
作者：
Denny BT;Kober H;Wager TD;Ochsner KN
用于感知和理解自我和他人的过程之间的区别在心理学和神经科学中受到了相当大的关注。大脑研究结果强调了不同区域的作用，特别是内侧前额叶皮层（mPFC），在支持对自我和他人的判断。我们使用多级核密度分析（MKDA）对107项自我和他人相关判断的神经影像学研究进行了荟萃分析。我们试图确定哪些大脑区域可靠地参与每种判断类型，特别是，mPFC的空间和功能组织与它们有关。相对于非心智化判断，自我和其他判断与活动mPFC，从腹侧到背侧的范围，以及共同激活的左颞顶交界处（TPJ）和后扣带回。自我和其他判断之间的直接比较显示，腹侧mPFC（vmPFC），以及左腹外侧PFC和左额叶皮层，更频繁地激活自我相关的判断，而背侧mPFC（dmPFC），除了双边TPJ和楔，更频繁地激活其他相关的判断。Logistic回归分析显示，腹侧和背侧mPFC位于功能梯度的两端：在个别研究中报告的z坐标预测研究是否涉及自我或其他相关的判断，这与mPFC的腹侧或背侧部分，分别。这些结果认为，一个分布式的，而不是localizationist帐户的mPFC组织和支持一个新兴的观点mPFC的功能异质性。
The distinction between processes used to perceive and understand the self and others has received considerable attention in psychology and neuroscience. Brain findings highlight a role for various regions, in particular the medial prefrontal cortex (mPFC), in supporting judgments about both the self and others. We performed a meta-analysis of 107 neuroimaging studies of self- and other-related judgments using Multilevel Kernel Density Analysis (MKDA). We sought to determine what brain regions are reliably involved in each judgment type, and in particular, what the spatial and functional organization of mPFC is with respect to them. Relative to non-mentalizing judgments, both self and other judgments were associated with activity in mPFC, ranging from ventral to dorsal extents, as well as common activation of the left temporoparietal junction (TPJ) and posterior cingulate. A direct comparison between self and other judgments revealed that ventral mPFC (vmPFC), as well as left ventrolateral PFC and left insula, were more frequently activated by self-related judgments, whereas dorsal mPFC (dmPFC), in addition to bilateral TPJ and cuneus, were more frequently activated by other-related judgments. Logistic regression analyses revealed that ventral and dorsal mPFC lay at opposite ends of a functional gradient: the z-coordinates reported in individual studies predicted whether the study involved self- or other-related judgments, which were associated with increasingly ventral or dorsal portions of mPFC, respectively. These results argue for a distributed rather than localizationist account of mPFC organization and support an emerging view on the functional heterogeneity of mPFC.
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影响因子：
3.9
作者：
Kober, Hedy;Wager, Tor D.
通讯作者：
Wager, Tor D.
影响因子：
7.6
作者：
FERGUSON, TJ;RULE, BG;CARLSON, D
通讯作者：
CARLSON, D
DOI：
10.1523/jneurosci.2335-09.2009
发表时间：
2009-09-16
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Kim MJ;Whalen PJ
通讯作者：
Whalen PJ
影响因子：
6.7
作者：
Bremner, J Douglas
通讯作者：
Bremner, J Douglas
影响因子：
4.1
作者：
KLEIN, SB;KIHLSTROM, JF
通讯作者：
KIHLSTROM, JF