Oropharyngeal cancer epidemic and human papillomavirus.
Oropharyngeal cancer epidemic and human papillomavirus.
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DOI：
10.3201/eid1611.100452
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发表时间：
2010-11
影响因子：
11.8
通讯作者：
Dalianis T
中科院分区：
文献类型：
--
作者：
Ramqvist T;Dalianis T
hpv阳性癌症患者年轻，缺乏传统的危险因素。越来越多的研究表明，人乳头瘤病毒（HPV）是口咽鳞状细胞癌（OSCC）的常见且日益增加的病因。因此，国际癌症研究机构已经承认，除了吸烟和饮酒之外，HPV也是OSCC的一个危险因素。最近，在芬兰、英国、荷兰、美国和瑞典，OSCC的发病率有所增加，hpv阳性肿瘤的比例也有所增加。根据这些数据和报告，HPV阳性癌症患者在年轻时就有了第一次性经验，并且有多个伴侣，我们假设在美国和北欧一些国家，OSCC发病率的增加是由于一种新的、主要是性传播的HPV流行。我们还建议进一步探索个体化治疗方式和预防性疫苗接种。
Patients with HPV-positive cancer were young and lacked traditional risk factors. Oropharyngeal Cancer Epidemic and HPV A growing body of research shows that human papillomavirus (HPV) is a common and increasing cause of oropharyngeal squamous cell carcinoma (OSCC). Thus, the International Agency for Research against Cancer has acknowledged HPV as a risk factor for OSCC, in addition to smoking and alcohol consumption. Recently, in Finland, the United Kingdom, the Netherlands, the United States, and Sweden, incidence of OSCC has increased, and an increase in the proportion of HPV-positive tumors was noted. On the basis of these data and reports indicating that patients with HPV-positive cancer have their first sexual experience at a young age and have multiple partners, we postulate that increased incidence of OSCC in the United States and some countries in northern Europe is because of a new, primarily sexually transmitted HPV epidemic. We also suggest that individualized treatment modalities and preventive vaccination should be further explored.
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DOI：
10.1086/597755
发表时间：
2009-05-01
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
D'Souza G;Agrawal Y;Halpern J;Bodison S;Gillison ML
通讯作者：
Gillison ML
影响因子：
9.4
作者：
Gravitt, PE;Peyton, CL;Wheeler, CM
通讯作者：
Wheeler, CM
影响因子：
7.7
作者：
Anaya-Saavedra, Gabriela;Ramirez-Amador, Velia;Garcia-Carranca, Alejandro
通讯作者：
Garcia-Carranca, Alejandro
影响因子：
8.8
作者：
Clavel, C;Masure, M;Bory, JP;Putaud, I;Mangeonjean, C;Lorenzato, M;Gabriel, R;Quereux, C;Birembaut, P
通讯作者：
Birembaut, P
影响因子：
254.7
作者：
Parkin, DM;Bray, F;Pisani, P
通讯作者：
Pisani, P