Spatiotemporal dynamics of low frequency fluctuations in BOLD fMRI of the rat.
Spatiotemporal dynamics of low frequency fluctuations in BOLD fMRI of the rat.
复制标题
DOI：
10.1002/jmri.21848
复制
发表时间：
2009-08
影响因子：
4.4
通讯作者：
Keilholz, Shella D.
中科院分区：
文献类型：
--
作者：
Majeed, Waqas;Magnuson, Matthew;Keilholz, Shella D.
关键词：
检查大鼠皮层低频波动的时空动态。从麻醉的大鼠中获取梯度回波平面回波成像图像（重复时间 = 100 毫秒）。进行功率谱分析以检测不同的频率峰值。获得了感兴趣的频率峰值的功能连接图。过滤后的时间序列中的图像显示为电影，以研究感兴趣频段数据中的时空模式。高时间和光谱分辨率可以分离生理噪声的主要成分并实现光谱细节的可视化。观察到两个具有不同特征的低频峰。第二个低频峰值的选择性可视化揭示了通常始于次级体感皮层并传播到初级运动皮层的活动波。迄今为止，对这些波动的分析主要集中在假设稳态条件下的功能网络的检测上。这些结果表明，对低频波动的时空动态的详细检查可以提供对大脑功能的更多了解，并为静息态功能磁共振成像数据的分析提供新的视角。
To examine spatiotemporal dynamics of low frequency fluctuations in rat cortex. Gradient-echo echo-planar imaging images were acquired from anesthetized rats (repetition time = 100 ms). Power spectral analysis was performed to detect different frequency peaks. Functional connectivity maps were obtained for the frequency peaks of interest. The images in the filtered time-series were displayed as a movie to study spatiotemporal patterns in the data for frequency bands of interest. High temporal and spectral resolution allowed separation of primary components of physiological noise and visualization of spectral details. Two low frequency peaks with distinct characteristics were observed. Selective visualization of the second low frequency peak revealed waves of activity that typically began in the secondary somatosensory cortex and propagated to the primary motor cortex. To date, analysis of these fluctuations has focused on the detection of functional networks assuming steady state conditions. These results suggest that detailed examination of the spatiotemporal dynamics of the low frequency fluctuations may provide more insight into brain function, and add a new perspective to the analysis of resting state fMRI data.
登录
查看更多内容
DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
5.7
作者：
Gonçalves, SI;de Munck, JC;da Silva, FHL
通讯作者：
da Silva, FHL
影响因子：
1.7
作者：
Peltier, SJ;Kerssens, C;Hu, XP
通讯作者：
Hu, XP
DOI：
10.1073/pnas.0705791104
发表时间：
2007-11-13
影响因子：
11.1
作者：
Lu, Hanbing;Zuo, Yantao;Stein, Elliot A.
通讯作者：
Stein, Elliot A.
影响因子：
5.7
作者：
Obrig, H;Neufang, M;Villringer, A
通讯作者：
Villringer, A