Why do viruses cause cancer? Highlights of the first century of human tumour virology.

Why do viruses cause cancer? Highlights of the first century of human tumour virology.
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DOI:
10.1038/nrc2961
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发表时间:
2010-12
期刊:
Nature reviews. Cancer
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其他
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2011年是弗朗西斯·佩顿·罗斯在禽流感病毒上进行的里程碑式的实验一百周年。从那时起,七种人类病毒被发现导致了全球10%-15%的人类癌症。病毒一直是现代癌症研究的核心,并为感染性和非感染性癌症原因提供了深刻的见解。这组不同的病毒揭示了先天免疫、免疫传感器和控制病毒感染和癌症的肿瘤抑制信号之间意想不到的联系。这篇时间线文章描述了人类肿瘤病毒的共同特征,并讨论了如何使用新技术来识别癌症的感染原因。
The year 2011 marks the centenary of Francis Peyton Rous’s landmark experiments on an avian cancer virus. Since then, seven human viruses have been found to cause 10–15% of human cancers worldwide. Viruses have been central to modern cancer research and provide profound insights into both infectious and non-infectious cancer causes. This diverse group of viruses reveals unexpected connections between innate immunity, immune sensors and tumour suppressor signalling that control both viral infection and cancer. This Timeline article describes common features of human tumour viruses and discusses how new technologies can be used to identify infectious causes of cancer.
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