Interrelationship Between Inflammatory Biomarkers and Collagen Remodeling Proteins in Atrial Fibrillation.
Interrelationship Between Inflammatory Biomarkers and Collagen Remodeling Proteins in Atrial Fibrillation.
复制标题
心房颤动中炎症生物标志物与胶原蛋白重塑蛋白之间的相互关系。
DOI：
10.1177/10760296231165055
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发表时间：
2023-01
影响因子：
2.9
通讯作者：
Syed, Mushabbar A.
中科院分区：
文献类型：
--
作者：
Odeh, Ameer;Dungan, Gabriel D.;Hoppensteadt, Debra;Siddiqui, Fakiha;Kantarcioglu, Bulent;Darki, Amir;Fareed, Jawed;Syed, Mushabbar A.
心房颤动（AF）是全球最常见的心律失常。炎症和结构重塑的左心房被认为是参与AF的发病机制。这项研究探讨了胶原蛋白重塑和炎症生物标志物在AF患者相比，健康对照组，以辨别其在AF中的作用。血浆样本收集AF患者进行首次AF消融术（n = 72），并与市售的健康受试者（n = 62）的人血浆样本进行比较。使用夹心ELISA试剂盒定量AF患者和对照人群中的胶原重塑生物标志物和炎症生物标志物。使用GraphPad prism进行统计分析。与健康对照组相比，AF患者的所有胶原重塑生物标志物和炎症生物标志物均出现统计学显著性升高。斯皮尔曼相关性分析表明炎症和胶原重塑生物标志物之间以及胶原生物标志物之间存在显著相关性。值得注意的是，发现CRP与TIMP-1、ICTP和PIIINP相关。IL 6和TIMP-1也被发现相互关联。此外，本研究中探讨的两种炎症标志物TNFα和IL 6与不同的胶原重塑肽之间存在相关性。AF患者中炎症生物标志物和胶原重塑蛋白的升高提示炎症和胶原更新增加。炎症生物标志物和胶原重塑蛋白之间的关联可能有助于它们在重塑过程中的调节和作用。
Atrial Fibrillation (AF) is the most prevalent cardiac arrhythmia worldwide. Inflammation and structural remodeling of the left atrium are thought to be involved in the pathogenesis of AF. This study explores collagen remodeling and inflammatory biomarkers in AF patients compared to healthy controls to discern their role in AF. Plasma samples were collected from AF patients undergoing first AF ablation (n = 72) and compared with commercially available human plasma samples from healthy subjects (n = 62). The collagen remodeling biomarkers and inflammatory biomarkers in the AF patients and control population were quantified using sandwich ELISA kits. GraphPad prism was used to perform statistical analyses. There was a statistically significant elevation in all the collagen remodeling biomarkers and inflammatory biomarkers in the AF patients compared to healthy controls. Spearman correlation analysis demonstrated significant correlations between inflammatory and collagen remodeling biomarkers, and among the collagen biomarkers. Of note, CRP was found to be correlated with TIMP-1, ICTP and PIIINP. IL6 and TIMP-1 were also found to be intercorrelated. Furthermore, correlations were noted among the different collagen remodeling peptides, and between TNFα and IL6, two of the inflammatory markers explored in this study. The elevation of the inflammatory biomarkers and collagen remodeling proteins in AF patients is suggestive of inflammation and increased collagen turnover. The association between inflammatory biomarkers and collagen remodeling proteins may contribute to their regulation and role in the remodeling process.
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影响因子：
24
作者：
Kallergis, Eleftherios M.;Manios, Emmanuel G.;Vardas, Panos E.
通讯作者：
Vardas, Panos E.
影响因子：
3.7
作者：
Kornej, Jelena;Buettner, Petra;Bollmann, Andreas
通讯作者：
Bollmann, Andreas
炎症和氧化应激在心房颤动中的作用。
影响因子：
5.5
作者：
Li, Jie;Solus, Joseph;Chen, Qingxia;Rho, Young Hee;Milne, Ginger;Stein, C. Michael;Darbar, Dawood
通讯作者：
Darbar, Dawood
影响因子：
3.7
作者：
Amdur RL;Mukherjee M;Go A;Barrows IR;Ramezani A;Shoji J;Reilly MP;Gnanaraj J;Deo R;Roas S;Keane M;Master S;Teal V;Soliman EZ;Yang P;Feldman H;Kusek JW;Tracy CM;Raj DS;CRIC Study Investigators
通讯作者：
CRIC Study Investigators
影响因子：
20.1
作者：
Gaudesius, G;Miragoli, M;Rohr, S
通讯作者：
Rohr, S